Join Us

At TCR² Therapeutics Inc, our inclusive and diverse team is passionate about curing cancer. We are a clinical-stage cell therapy company pioneering the development of novel T cell therapies by utilizing our TRuC platform. Our lead autologous cell product gavo-cel (TC-210) is being studied in a Phase 1/2 trial for treatment refractory mesothelin-expressing solid tumors. In addition, our emerging and dynamic oncology pipeline focuses on a series of next-generation enhancements, novel targets and an allogeneic platform which may further improve clinical outcomes and broaden patient access.

We are headquartered in Cambridge, Massachusetts with clinical manufacturing facilities in Stevenage, UK and Rockville, MD. This role can be based either in Cambridge, MA or remotely within the East Coast. 

We are looking for a Director, Clinical Quality Assurance (GCP) to join our growing Quality Assurance department to provide quality oversight for our clinical trials. You will report to our US Quality Director and work closely with Clinical Operations, our Contract Research Organizations, Medical Affairs and Regulatory, as needed. As the Director, Clinical QA Systems you will be primarily responsible for developing, improving and maintaining Phase Appropriate Quality processes and procedures supporting Good Clinical Practice (GCP).This will role will be instrumental at preparing for and guiding us into pivotal trial. 

Responsibilities:

• Serve as the primary contact in QA for the oversight of Clinical Studies in the US and Canada to ensure compliance with all GCP’s from collection, labeling, distribution and site qualification to ensure compliance with all Regulatory requirements in the country the study is conducted
• Establish and maintain phase appropriate Quality Systems to support clinical studies. (including pharmacovigilance activities?). Implement (or assist with) GXP-compliant policies and procedures that are consistent, robust and integrated into the TCR2 Quality Management System
• Provide professional expertise and guidance on Good Clinical Practice (GCP) and applicable regulations to clinical development teams to proactively identify compliance issues/risks and recommend mitigation
• Plan, oversee/perform and follow-up audits of CROs, external laboratories, clinical trial sites
• Establish/ensure/remediate as needed the current quality processes, systems and procedures associated with clinical studies
• Collaborate with cross-functional management, including the Head of Clinical, Medical Affairs, Regulatory Affairs, and Information Technology to drive clinical process improvements and alignments

Requirements:

• BS or MS preferred with 8+ years of experience in the pharmaceutical, Biologics or health industry with demonstrated knowledge or experience in GCP Compliance
• Thorough understanding of clinical drug development, GCP, and familiarity with regulatory (FDA, Health Canada, and other global regulations) requirements for the conduct of clinical trials, including investigator-initiated studies
• Advanced knowledge in the conduct and reporting of audits and the translation of findings into corrective actions plans that mitigate risks to the company, to safety and data integrity.
• The ability to represent QA cross-functionally and globally; to apply understanding of the team’s place in the larger organization, and discuss changes, progress, and issues as they relate to other areas
• Collaborative team player with a positive attitude and ability to think and act quickly to identify creative solutions to complex problems
• GCP Quality Assurance registration/certification preferred

At TCR² Therapeutics Inc, our inclusive and diverse team is passionate about curing cancer. We are a clinical-stage cell therapy company pioneering the development of novel T cell therapies by utilizing our TRuC platform. Our lead autologous cell product gavo-cel (TC-210) is being studied in a Phase 1/2 trial for treatment refractory mesothelin-expressing solid tumors. In addition, our emerging and dynamic oncology pipeline focuses on a series of next-generation enhancements, novel targets and an allogeneic platform which may further improve clinical outcomes and broaden patient access.

We are headquartered in Cambridge, Massachusetts with clinical manufacturing facilities in Stevenage, UK and Rockville, MD. This role will be based in Cambridge, MA.

TCR2 has embarked on establishing a cGMP manufacturing operations to provide manufacturing capacity for Phase 1 and Phase 2 operations, and beyond, for the TRuCTM T cell platform. We are looking for a Sr. Quality Assurance Associate who will support quality operations under the Quality Management System environment including product and batch record review, tracking training and deviations, change management, equipment validation,  and assisting with documentation control activities. In addition, the Sr. Quality Assurance Associate will support research operating procedure development, document control, and tracking training for the non-GMP departments.

Responsibilities:

• Maintain quality supporting documentation to facilitate GMP production including tech transfers and equipment qualification/validation at CMOs
• Perform review of manufacturing records and perform batch release for clinical lots.
• Manage Quality Change Control projects
• Review Change Control records impacting T cell therapy product and provide QA support for other changes
• Provide investigational support for deviations for the manufacture, testing, and shipping of raw materials or drug product
• Write and revise quality SOPs and associated documentation to support GMP production
• Support the quality vendor approval for suppliers, contractors and service providers, assist with external audits
• Conduct training for GMP and GDP processing
• Perform deviation review and implementation of CAPA to improve product quality
• Liaison with UK Quality department on quality related issues and provide support as needed

Requirements:

• Bachelor’s degree in the biological sciences or related field
• Minimum of 5 years GMP experience in a biotech, or biologics operation, or equivalent education/work experience
• Knowledge of Quality Management System elements and experience in maintaining and improving systems supporting the QMS
• Prior experience in a quality function (quality assurance or quality control), preferably in a commercial environment
• Working knowledge and ability to apply GMPs in conformance with FDA, MHRA, EU and ICH standards, preferably gained from working in a manufacturing or QC environment
• Good interpersonal, verbal and written communication skills
• Comfortable in a fast-paced small company environment with minimal direction
• External auditing experience preferred

At TCR² Therapeutics Inc, our inclusive and diverse team is passionate about curing cancer. We are a clinical-stage cell therapy company pioneering the development of novel T cell therapies by utilizing our TRuC platform. Our lead autologous cell product gavo-cel (TC-210) is being studied in a Phase 1/2 trial for treatment refractory mesothelin-expressing solid tumors. In addition, our emerging and dynamic oncology pipeline focuses on a series of next-generation enhancements, novel targets and an allogeneic platform which may further improve clinical outcomes and broaden patient access. We are headquartered in Cambridge, Massachusetts with clinical manufacturing facilities in Stevenage, UK and Rockville, MD. This role will be based in Cambridge, MA. 

We are growing and looking for Process Development Co-Ops. You will have the opportunity to either work on with the T Cell Production team on the development of a robust and scalable manufacturing process.

This role is a unique opportunity to learn and advance your career development actively working with a close team in a fast-paced and highly collaborative environment. We are experiencing hyper-growth, we are looking at this as a long-term opportunity and real opportunity for conversion for students who are nearing graduation. 

 Responsibilities:

• Learn and utilize new skills to help develop T Cell Production processes including T cell isolation, enrichment, activation, transduction, expansion, and cryopreservation
• Learn the execution of key projects through both independent execution and collaboration with other team members
• Learn to generate data through well-defined and executed design of experiment studies, while organizing and prioritizing work to meet timelines

 Requirements:

• You are in a BS or MS program in biotechnology, immunology, cell biology or related discipline and 2 years of industry experience preferred
• You must have hands on technical experience with cell culture handling. Experience with in-vitro cell-based assays involving flow cytometry is preferred.
• Outstanding critical thinking and organizational skills, leadership, and attention to detail
• Team-based candidate interested in a fast-paced, exciting, start-up environment!

At TCR² Therapeutics Inc, our inclusive and diverse team is passionate about curing cancer. We are a clinical-stage cell therapy company pioneering the development of novel T cell therapies by utilizing our TRuC platform. Our lead autologous cell product gavo-cel (TC-210) is being studied in a Phase 1/2 trial for treatment refractory mesothelin-expressing solid tumors. In addition, our emerging and dynamic oncology pipeline focuses on a series of next-generation enhancements, novel targets and an allogeneic platform which may further improve clinical outcomes and broaden patient access.

We are headquartered in Cambridge, Massachusetts with clinical manufacturing facilities in Stevenage, UK and Rockville, MD. This role will be based in Cambridge, MA. 

We are looking for an Associate Scientist to develop novel molecular assays to detect and quantify impurities in our drug product and process. This position will also participate in T Cell product characterization studies. You will report to our Scientist, Analytical Development and work closely with the T Cell Process Development team.

Your primary responsibilities will include research and development of assays to detect process-related impurities during the T Cell production process, and assay qualification. Authoring work instructions, protocols, reports, and presentations will be critical in this role. Additional activities could include improvement of existing assays and routine testing of samples throughout the T Cell production process, including the final product. This position represents an excellent opportunity for career development, working closely with experienced scientists in a fast-paced and highly collaborative environment.

Responsibilities:

• Develop new analytical methods in-house and manage method development and/or custom reagent development at contract research organizations as necessary.
• Execute a variety of analytical methods, including cell-based assays, ELISAs, and flow cytometry.
• Analyze data, document results, and write corresponding technical reports for product characterization studies.
• Write protocols and reports for internal and/or regulatory use.
• Work closely and effectively with CMC stakeholders, including Process Development and Quality.
• This is a hands-on position requiring execution of laboratory experiments.

Requirements:

• M.S. in biochemistry, chemical engineering, or related discipline with 4+ years relevant industry experience, or B.S. with 5+ years relevant industry experience.
• Industry experience is required for this position.
• Experience with analytical assays required, with emphasis on cell and plate-based assays.
• Strong technical writing skills with industry experience writing technical protocols, reports, and procedures is required.
• Experience with flow cytometry, mammalian cell culture, and/or primary human cells a plus.
• Experience with statistical analysis software, e.g. JMP, is a plus.
• Outstanding critical thinking and organizational skills, leadership, and attention to detail.
• Team-based candidate interested in a fast-paced, exciting, start-up environment!

At TCR² Therapeutics Inc, our inclusive and diverse team is passionate about curing cancer. We are a clinical-stage cell therapy company pioneering the development of novel T cell therapies by utilizing our TRuC platform. Our lead autologous cell product gavo-cel (TC-210) is being studied in a Phase 1/2 trial for treatment refractory mesothelin-expressing solid tumors. In addition, our emerging and dynamic oncology pipeline focuses on a series of next-generation enhancements, novel targets and an allogeneic platform which may further improve clinical outcomes and broaden patient access.

We are headquartered in Cambridge, Massachusetts with clinical manufacturing facilities in Stevenage, UK and Rockville, MD. This role will be based in Cambridge, MA. 

We are looking for an Associate Director to join the Analytical Development group as a CMC Analytical Product lead for our gavo-cel product and Regulatory submission SME. You will report to our head of Analytical Development and work closely with the Process Development, Regulatory, and Translational Research teams.

Responsibilities as a CMC analytical product lead will include a variety of activities as the product expert, including authorship of regulatory submissions and supporting documents along with design, coordination, and execution of studies to better understand product attributes in support of regulatory filings and other CMC activities. You will additionally be responsible for cross-functional collaboration to support successful manufacturing and testing of T Cell drug products and lentiviral vectors for clinical trials. Additional activities include participation in the evaluation of new technologies, and support of the technology transfer to internal and external manufacturing partners. The position represents an excellent opportunity for career development, working closely with experienced scientists in a fast-paced and highly collaborative environment.

Responsibilities:

• As gavo-cel analytical product lead, contribute to and execute the analytical strategy through planning and authorship CMC sections of regulatory filings and supporting documents.
• As T Cell drug product SME, evaluate, plan, and document studies for product understanding.
• Assist junior team members with experimental design, data analysis, interpretation, troubleshooting, and technical report authorship.
• Write protocols, reports, policies, risk assessments, and other related procedures for regulatory support, technology transfer, and internal use.
• Work closely and effectively with our internal manufacturing group and/or CMOs to ensure appropriate implementation of analytical methods transferred from TCR2.
• Provide direction, management, and mentorship for junior team members.
• This is a Cambridge, Massachusetts based position requiring supervision of junior laboratory staff and occasional troubleshooting or other laboratory oversight.

Requirements:

• Ph.D. in biochemistry, chemical engineering, or related discipline with at least 6 years of relevant industry experience, M.S. with 10+ years relevant industry experience, or B.S. with 12+ years relevant industry experience.
• Strong technical writing skills with industry experience writing regulatory documents, including CMC sections of INDs, BLA, and/or MAAs. Additional experience writing technical protocols, reports, and procedures required.
• Experience in cell and gene therapy strongly preferred; experience with analytical comparability a plus.
• Experience with analytical assay development required, with emphasis on flow cytometry.
• Experience with qPCR, ddPCR, ELISA, and/or cell-based assays a plus.
• Experience with method qualification and/or validation.
• Outstanding critical thinking and organizational skills, leadership, and attention to detail
• Team-based candidate interested in a fast-paced, exciting, start-up environment!

At TCR² Therapeutics Inc, our inclusive and diverse team is passionate about curing cancer. We are a clinical-stage cell therapy company pioneering the development of novel T cell therapies by utilizing our TRuC platform. Our lead autologous cell product gavo-cel (TC-210) is being studied in a Phase 1/2 trial for treatment refractory mesothelin-expressing solid tumors. In addition, our emerging and dynamic oncology pipeline focuses on a series of next-generation enhancements, novel targets and an allogeneic platform which may further improve clinical outcomes and broaden patient access. We are headquartered in Cambridge, Massachusetts with clinical manufacturing facilities in Stevenage, UK and Rockville, MD. This role will be based in Cambridge, MA. 

We are looking for a Principal Scientist/Associate Director to drive method development for our TRuC T Cells. You will report to our head of Analytical Development and work closely with the Regulatory and T Cell Process Development teams.

The successful candidate will join the Analytical Development Team to drive method development for T Cell release testing and characterization. Primary responsibilities include design of studies for method development and qualification, authorship of technical protocols and reports, coordination of testing, and troubleshooting as needed. Additional activities include support of method transfer to internal and external manufacturing partners. The position represents an excellent opportunity for career development, working closely with experienced scientists in a fast-paced and highly collaborative environment.

Responsibilities:

• Manage a team focused on T Cell method development, including provision of mentorship, guideance, and hiring of new team members.
• Provide relevant updates to CMC leadership on T Cell analytical methods, and contribute to CMC strategy for release testing and characterization of T Cell drug product.
• Manage execution of analytical methods to support assay development and product understanding for lentiviral vectors and T Cells.
• Design experiments, assist with data analysis, interpretation and troubleshooting and write corresponding technical reports for method development and product understanding studies.
• Coordinate and schedule routine testing for junior group members and prioritize work to meet timelines.
• Write protocols and operating procedures for technology transfer and internal use.
• Work closely and effectively with our internal manufacturing group and/or CMOs for technology transfer and support.
• This position requires some in-person attendance for oversight of laboratory work, troubleshooting, and team leadership. 

Requirements:

• Ph.D. in biochemistry, chemical engineering, or related discipline with at least 4 years of relevant industry experience, M.S. with 10+ years relevant industry experience, or B.S. with 12+ years relevant industry experience.
• Strong technical writing skills with industry experience writing technical protocols, reports, and procedures required.
• Experience with analytical assay development required, with emphasis on flow cytometry and plate-based bioassays.
• Experience with method qualification and/or validation a plus.
• Experience with flow cytometry and cell-based assays required. Experience with primary T cells a plus.
• Outstanding critical thinking and organizational skills, leadership, and attention to detail
• Team-based candidate interested in a fast-paced, exciting, start-up environment!

At TCR² Therapeutics Inc, our inclusive and diverse team is passionate about curing cancer. We are a clinical-stage cell therapy company pioneering the development of novel T cell therapies by utilizing our TRuC platform. Our lead autologous cell product gavo-cel (TC-210) is being studied in a Phase 1/2 trial for treatment refractory mesothelin-expressing solid tumors. In addition, our emerging and dynamic oncology pipeline focuses on a series of next-generation enhancements, novel targets and an allogeneic platform which may further improve clinical outcomes and broaden patient access.

We are headquartered in Cambridge, Massachusetts with clinical manufacturing facilities in Stevenage, UK and Rockville, MD. This role will be based in Cambridge, MA. 

We are looking for an Associate Scientist to perform testing of cellular drug products using complex bioassays and participate in T Cell product characterization studies. You will report to our Principal Scientist, Analytical Development and work closely with the Regulatory and T Cell Process Development teams.

Your primary responsibilities will include testing of manufactured T Cells, and characterization of engineered T Cells for product and attribute understanding. Additional activities could include evaluation of new technologies, improving existing assays, and authorship of regulatory documents. The position represents an excellent opportunity for career development, working closely with experienced scientists in a fast-paced and highly collaborative environment.

Responsibilities:

• Execute a variety of analytical methods, including cell based assays, ELISAs, and flow cytometry.
• Analyze data, document results, and write corresponding technical reports for product characterization studies.
• Write protocols and reports for internal and/or regulatory use.
• Work closely and effectively with CMC stakeholders, including Process Development, Regulatory, and Quality.
• This is a hands-on position requiring execution of laboratory experiments.

Requirements:

• M.S. in biochemistry, chemical engineering, or related discipline with 4+ years relevant industry experience, or B.S. with 5+ years relevant industry experience.
• Industry experience is required for this position.
• Experience with analytical assays required, with emphasis on cell and plate-based assays.
• Experience with flow cytometry, mammalian cell culture, and/or primary human cells a plus.
• Strong technical writing skills with industry experience writing technical protocols, reports, and procedures is required.
• Outstanding critical thinking and organizational skills, leadership, and attention to detail.
• Team-based candidate interested in a fast-paced, exciting, start-up environment!

At TCR² Therapeutics Inc, our inclusive and diverse team is passionate about curing cancer. We are a clinical-stage cell therapy company pioneering the development of novel T cell therapies by utilizing our TRuC platform. Our lead autologous cell product gavo-cel (TC-210) is being studied in a Phase 1/2 trial for treatment refractory mesothelin-expressing solid tumors. In addition, our emerging and dynamic oncology pipeline focuses on a series of next-generation enhancements, novel targets and an allogeneic platform which may further improve clinical outcomes and broaden patient access.

We are headquartered in Cambridge, Massachusetts with clinical manufacturing facilities in Stevenage, UK and Rockville, MD. This role will be based in Cambridge, MA. 

The TCR2 team is expanding, and we are hiring a Manager to join our team to help coordinate and manage lentiviral vector clinical and commercial manufacturing efforts to support our growing pipeline. You will report to an Associate Director on the team and work closely with the process development team, and cross-functionally with analytical development, quality, and regulatory teams during execution as required.

This role is a unique opportunity for you to advance your career development, actively working with a close team in a fast-paced and highly collaborative environment.

Responsibilities: 

• Aid in coordination, documentation, and execution of process characterization execution activities to support late-stage manufacturing.
• Utilize project management and communication skills to help coordinate project plans and ensure successful execution of activities to support lentiviral vector generation.
• Lead project execution from initial internal tech transfers to external execution and material release for clinical manufacturing.
• Provide technical support for manufacturing planning, execution, and investigations as required.
• Author and review reports to support technology transfers from process development, manufacturing investigations, final product comparability, and regulatory filing support as needed.
• Present executed work at scientific presentations and meetings.

Requirements: 

• BS or MS in chemical engineering, biochemical engineering, or related discipline and at least 5 years of industry experience.
• Technical experience with vector development and/or manufacturing is required, including solid foundational knowledge of tech transfer requirements and GMP manufacturing systems.
• Familiarity with authoring documentation to support quality investigations as well as regulatory submissions is preferred.
• Outstanding critical thinking and organizational skills, leadership, and attention to detail. 
• Team-based candidate interested in a fast-paced, exciting, start-up environment. 

At TCR² Therapeutics Inc, our inclusive and diverse team is passionate about curing cancer. We are a clinical-stage cell therapy company pioneering the development of novel T cell therapies by utilizing our TRuC platform. Our lead autologous cell product gavo-cel (TC-210) is being studied in a Phase 1/2 trial for treatment refractory mesothelin-expressing solid tumors. In addition, our emerging and dynamic oncology pipeline focuses on a series of next-generation enhancements, novel targets and an allogeneic platform which may further improve clinical outcomes and broaden patient access.

We are headquartered in Cambridge, Massachusetts with clinical manufacturing facilities in Stevenage, UK and Rockville, MD. This role will be based in Cambridge, MA. 

We are growing and hiring a Scientist/Sr. Scientist to join our Process Development team. You will report to our Associate Director of Vector Process Development and work closely across the Process Development group on the purification of lentiviral vectors and development of a robust and scalable manufacturing process. The role is a unique opportunity for you to advance your career development, actively working with a close team in a fast-paced and highly collaborative environment.

Responsibilities: 

• Help develop, optimize, and scale downstream purification processes for viral vectors
• Optimize parameters through well-defined design of experiment studies
• Analyze and document scientific results for IND enabling study content
• Mentor and manage associates during execution of internal and external tasks
• Write protocols and reports to support technology transfers from process development to manufacturing
• Organize and prioritize work to meet timelines with ability to execute on multiple projects
• Represent TCR2 at scientific presentations and meetings

Requirements: 

• MS with 5 years or Ph.D. with 3 years industry experience with degree in chemical engineering, biochemical engineering, or related discipline
• Technical experience with purification applications, including extensive knowledge of filtration and chromatography applications is required
• Additional experience with formulation and fill/finish activities is preferred
• Experience with tech transfer and GMP manufacturing systems is preferred
• Experience leading small teams in lab experimental execution is preferred
• Outstanding critical thinking and organizational skills, leadership, and attention to detail 
• Team-based candidate interested in a fast-paced, exciting, start-up environment! 

At TCR² Therapeutics Inc, our inclusive and diverse team is passionate about curing cancer. We are a clinical-stage cell therapy company pioneering the development of novel T cell therapies by utilizing our TRuC platform. Our lead autologous cell product gavo-cel (TC-210) is being studied in a Phase 1/2 trial for treatment refractory mesothelin-expressing solid tumors. In addition, our emerging and dynamic oncology pipeline focuses on a series of next-generation enhancements, novel targets and an allogeneic platform which may further improve clinical outcomes and broaden patient access.

We are headquartered in Cambridge, Massachusetts with clinical manufacturing facilities in Stevenage, UK and Rockville, MD. This role will be based in Cambridge, MA. 

We are looking for a Senior Research Associate to join the T Cell Process Development team to work on cutting edge TRuC T cell manufacturing process, and to support regulatory filings. You will report to our Senior Scientist, T Cell Process Development and work closely with the Analytical Development group and other teams as needed. This is an excellent opportunity for career development, working closely with experienced scientists in a fast-paced and highly collaborative environment to support the production and in vitro characterizations of novel autologous and allogeneic TRuC-T cells programs.

Responsibilities:

• Perform T cell isolation, enrichment, activation, transduction, expansion and cryopreservation utilizing functionally closed cell systems
• Perform in-vitro cellular assays involving flow cytometric, molecular and functional characterization of genetically engineered primary T cells
• Collaborate with the Analytical Development group in improving primary T-cells characterization
• Contribute to the development and production of TRuC™ T-cells for various pipeline programs and in-vivo animal studies
• Analyze results and document scientific results for IND enabling studies

Requirements:

• B.S./M.S. degree in immunology, cell biology or similar discipline with 2+ years of experience in biotech and/or Pharma
• Experience in analytical assay execution and development, particularly cell based toxicity assays is required and flow cytometry, ELISA, PCR is preferred 
• Experience working with lentiviral and transduction of human T cells along with functionally closed systems are highly desirable. If no experience this is an opportunity to learn!
• Excellent attention to detail and problem-solving skills, ability to analyze and interpret data.
• Must be a highly effective collaborator with strong written/verbal communication and interpersonal skills

At TCR² Therapeutics Inc, our inclusive and diverse team is passionate about curing cancer. We are a clinical-stage cell therapy company pioneering the development of novel T cell therapies by utilizing our TRuC platform. Our lead autologous cell product gavo-cel (TC-210) is being studied in a Phase 1/2 trial for treatment refractory mesothelin-expressing solid tumors. In addition, our emerging and dynamic oncology pipeline focuses on a series of next-generation enhancements, novel targets and an allogeneic platform which may further improve clinical outcomes and broaden patient access. We are headquartered in Cambridge, Massachusetts with clinical manufacturing facilities in Stevenage, UK and Rockville, MD. This role will be based in Cambridge, MA. 

We are growing and hiring a Research Associate/Senior Research Associate (Dependent on experience) to join our Process Development team. You will report to a Senior Scientist on the team and work with the rest of the team for the purification of lentiviral vectors, and development of a robust and scalable manufacturing process.

This role is a unique opportunity for you learn and advance your career development actively working with a close team in a fast-paced and highly collaborative environment.

Responsibilities: 

• Utilize skills to help develop, optimize, and scale downstream purification operations for our viral vector process
• Lead key projects through both independent execution and collaboration with other team members
• Generate data through well-defined and executed design of experiment studies, while organizing and prioritizing work to meet timelines 
• Write protocols and reports to support executed work and technology transfers from process development to manufacturing
• Present executed work at scientific presentations and meetings

Requirements: 

• BS or MS in chemical engineering, biochemical engineering, or related discipline and at least 3 years of industry experience
• Technical experience with purification applications is required, including solid foundational knowledge of filtration and chromatography applications
• Additional experience with formulation and fill/finish activities is a plus
• Experience with tech transfer and GMP manufacturing systems is preferred
• Outstanding critical thinking and organizational skills, leadership, and attention to detail 
• Team-based candidate interested in a fast-paced, exciting, start-up environment! 

At TCR² Therapeutics Inc, our inclusive and diverse team is passionate about curing cancer. We are a clinical-stage cell therapy company pioneering the development of novel T cell therapies by utilizing our TRuC platform. Our lead autologous cell product gavo-cel (TC-210) is being studied in a Phase 1/2 trial for treatment refractory mesothelin-expressing solid tumors. In addition, our emerging and dynamic oncology pipeline focuses on a series of next-generation enhancements, novel targets and an allogeneic platform which may further improve clinical outcomes and broaden patient access.

We are headquartered in Cambridge, Massachusetts with clinical manufacturing facilities in Stevenage, UK and Rockville, MD. This role will be based in Cambridge, MA. 

We are looking for a Principal Scientist to join the T Cell Process Development group to work on the late-stage development, characterization, and commercialization of novel autologous and allogeneic TRuC-T cell programs as well as support regulatory filings. Under minimal supervision, you will be expected to design, manage, and perform experiments, organizing, analyzing, and carefully documenting results, as well as communicate findings. This is an excellent opportunity for career development, working closely with the Viral Vector and Analytical Development groups leading a team of scientists and associates in a fast-paced and highly collaborative environment.

Responsibilities:

• Individually contributing and leading a team of 2-3 Scientists/ associates to establish small scale model(s) for T-cell Manufacturing.
• Lead the design and execution of process development studies to develop a thorough understanding of operating and performance parameters (Design space) for T cell manufacturing processes.
• Performs gap analysis and risk assessments to identify problems and deficiencies, as well as provide recommendations for studies and solutions to manufacturing process.
• Develops and leads strong collaborative relationships with internal and external groups. 
• Lead tech transfer activities for T-cell operations to manufacturing sites.
• Support the development of standard operating procedures, FMEA, batch records, and analytical sampling plans.
• Serve as Subject Matter Expert (SME) for operations for T-cell Manufacturing.

Requirements:

• M.S. or Ph.D. in Engineering, science or biology science.
• M.S. with 7+ years or Ph.D. with 4+ years of relevant industry experience. 
• Experience with process characterization, scale-up and/or technology transfer required.
• Experience using Design of Experiment (DOE) and statistical analysis using tools such as JMP.
• Familiarity with commercialization of cell-based therapeutics preferred.
• Experience with functionally closed systems preferred.
• Outstanding critical thinking and organizational skills, leadership, and attention to detail.
• Comfortable in a fast-paced small company environment with minimal direction and able to adjust workload based upon changing priorities.

At TCR² Therapeutics Inc, our inclusive and diverse team is passionate about curing cancer. We are a clinical-stage cell therapy company pioneering the development of novel T cell therapies by utilizing our TRuC platform. Our lead autologous cell product gavo-cel (TC-210) is being studied in a Phase 1/2 trial for treatment refractory mesothelin-expressing solid tumors. In addition, our emerging and dynamic oncology pipeline focuses on a series of next-generation enhancements, novel targets and an allogeneic platform which may further improve clinical outcomes and broaden patient access.

We are headquartered in Cambridge, Massachusetts with clinical manufacturing facilities in Stevenage, UK and Rockville, MD. This role will be based in Cambridge, MA. 

We are looking for a Senior Scientist to join the T Cell Process Development group to work on early stage process development of novel pipeline autologous and allogeneic TRuC-T cell programs as well as support regulatory filings. Under minimal supervision, you will be expected to design, manage, and perform experiments, organizing, analyzing, and carefully documenting results, as well as communicate findings. This is an excellent opportunity for career development, working closely with the Viral Vector and Analytical Development groups leading a team of associates in a fast-paced and highly collaborative environment.

Responsibilities:

• Evaluate, develop and implement functionally closed systems for T cell isolation, enrichment, activation, transduction, expansion and cryopreservation.
• Lead the design and execution of process development studies to support pre-IND / IND activities.
• Perform in-vitro cellular assays involving flow cytometric, molecular and functional characterization of genetically engineered primary T cells.
• Support production of TRuC™ T-cells for various pipeline programs and in-vivo animal studies.
• Analyze results and document scientific results for critical regulatory filings.
• Lead tech transfer activities for T-cell operations to manufacturing sites.
• Support the development of standard operating procedures, FMEA, batch records, and analytical sampling plans.
• Serve as Subject Matter Expert (SME) for operations for T-cell Manufacturing.

Requirements:

• M.S. or Ph.D. degree in Engineering, immunology, cell biology or similar discipline. 
• M.S. with 5+ years or Ph.D. with 2+ years of relevant industry experience.
• Experience in analytical assay execution and development, particularly flow cytometry, ELISA, and cell based functional assays.
• Outstanding critical thinking and organizational skills, leadership, and attention to detail.
• Experience with functionally closed systems or early technology evaluations  highly desirable.
• Experience with cGMP manufacturing requirements preferred.
• Desire to build a scalable manufacturing process and be a part of a growing company.
• Outstanding critical thinking and organizational skills, leadership, and attention to detail.
• Comfortable in a fast-paced small company environment with minimal direction and able to adjust workload based upon changing priorities.

At TCR² Therapeutics Inc, our inclusive and diverse team is passionate about curing cancer. We are a clinical-stage cell therapy company pioneering the development of novel T cell therapies by utilizing our TRuC platform. Our lead autologous cell product gavo-cel (TC-210) is being studied in a Phase 1/2 trial for treatment refractory mesothelin-expressing solid tumors. In addition, our emerging and dynamic oncology pipeline focuses on a series of next-generation enhancements, novel targets and an allogeneic platform which may further improve clinical outcomes and broaden patient access.

We are headquartered in Cambridge, Massachusetts with clinical manufacturing facilities in Stevenage, UK and Rockville, MD. This role will be based in Cambridge, MA. 

We are looking for a Scientist to join the T Cell Process Development group to work on the late-stage development, characterization, and commercialization of novel autologous and allogeneic TRuC-T cell programs as well as support regulatory filings. You will support / lead experimental design, execution, analysis, and reporting of experiments related to design space and process characterization activities for T-cell manufacturing. This is an excellent opportunity for career development, working closely with the Viral Vector and Analytical Development groups comprised of experienced scientists and associates in a fast-paced and highly collaborative environment.

Responsibilities:

• Support development of small-scale model(s) for T cell Manufacturing.
• Support / lead the design and execution of process development studies to develop a thorough understanding of operating and performance parameters (Design space) for T cell manufacturing processes.
• Perform in-vitro cellular assays involving flow cytometric, molecular and functional characterization of genetically engineered primary T cells.
• Perform gap analysis and risk assessments to identify problems and deficiencies, as well as provide recommendations for studies and solutions to manufacturing process. 
• Lead tech transfer activities for T-cell operations to manufacturing sites.
• Support the development of standard operating procedures, FMEA, batch records, and analytical sampling plans.
• Serve as Subject Matter Expert (SME) for operations for T-cell Manufacturing.
• Support regulatory agency filings.

Requirements:

• B.S., M.S. or Ph.D. in Engineering, science or biology science.
• B.S. with 6+ years or M.S. with 3+ years or Ph.D. with 1+ years of relevant industry experience. 
• Experience using Design of Experiment (DOE) and statistical analysis using tools such as JMP.
• Experience with process characterization, scale-up and/or technology transfer preferred.
• Familiarity with commercialization of cell-based therapeutics preferred.
• Experience with functionally closed systems preferred.
• Outstanding critical thinking and organizational skills, leadership, and attention to detail.
• Comfortable in a fast-paced small company environment with minimal direction and able to adjust workload based upon changing priorities.

At TCR² Therapeutics Inc, our inclusive and diverse team is passionate about curing cancer. We are a clinical-stage cell therapy company pioneering the development of novel T cell therapies by utilizing our TRuC platform. Our lead autologous cell product gavo-cel (TC-210) is being studied in a Phase 1/2 trial for treatment refractory mesothelin-expressing solid tumors. In addition, our emerging and dynamic oncology pipeline focuses on a series of next-generation enhancements, novel targets and an allogeneic platform which may further improve clinical outcomes and broaden patient access. We are headquartered in Cambridge, Massachusetts with clinical manufacturing facilities in Stevenage, UK and Rockville, MD. This role will be based in Cambridge, MA. 

We are seeking a talented Senior Scientist/Principal Scientist with a strong background in cancer immunotherapy to support the advancement of TCR2’s pipeline of targeted TRuC T cell therapies. Reporting the Sr. Director of Pharmacology, you will possess hands-on expertise in the ex vivo isolation and immunoprofiling of tumor-infiltrating T cells from mouse models and will apply these skills to advance our understanding of TRuC T cell function and behavior as we select lead candidates. 

Responsibilities:

• Perform ex vivo assessments of tumor-infiltrarting TRuC T cell functionality and behavior using various technologies, including but not limited to flow cytometry, MSD, Luminex, IHC, Nanostring/RNA-seq
• Develop novel assays and explore new technologies for immunoprofiling of TRuC T cells
• Define the pharmacokinetic and pharmacodynamic properties of TRuC T cells by longitudinal analysis of TRuC T cell expansion, immunophenotype, biodistribution, gene expression profiling, and cytokine release
• Generate mechanistic and functional data to guide the selection of TRuC T cell lead candidates and identification of optimal enhancement strategies
• Serve as a member of cross-functional program teams and lead the design of ex vivo analysis endpoints for in vivo pharmacology studies
• Present research findings to internal and external audiences

Requirements:

• Ph.D.* in biology-related discipline with 1-2+ years of post-Ph.D. research experience, in adoptive T cell therapies or immunology
• Hands-on expertise with the functional profiling of T cells using flow cytometry (high dimensional/multiparameter), gene expression profiling (Nanostring, RNA-seq), IHC, and other technologies
• Experience with assessing the efficacy of immunotherapies in syngeneic and/or xenograft tumor models is highly desirable
• Well-versed in T cell therapy pharmacokinetic and pharmacodynamic ex vivo endpoints, including T cell expansion, persistence, biodistribution, cytokine release, and phenotype
• Excellent oral and written communication skills with experience leading the authorship of manuscripts; experience authoring regulatory documents a plus
• Keen attention to detail with excellent organizational and record-keeping skills

*Candidates without a Ph.D. may be considered if they have commensurate experience

At TCR² Therapeutics Inc, our inclusive and diverse team is passionate about curing cancer. We are a clinical-stage cell therapy company pioneering the development of novel T cell therapies by utilizing our TRuC platform. Our lead autologous cell product gavo-cel (TC-210) is being studied in a Phase 1/2 trial for treatment refractory mesothelin-expressing solid tumors. In addition, our emerging and dynamic oncology pipeline focuses on a series of next-generation enhancements, novel targets and an allogeneic platform which may further improve clinical outcomes and broaden patient access.

We are headquartered in Cambridge, Massachusetts with clinical manufacturing facilities in Stevenage, UK and Rockville, MD. This role will be based in Cambridge, MA. 

We are looking for a Senior Research Associate / Associate Scientist to join the Translational Science team and assist in functionally characterizing patient-derived clinical samples through in vitro tissue culture assays. You will report to a Senior Scientist in Translational Sciences, and work closely with other experienced scientists in the Translational Sciences and R&D Teams to support clinical-level programs. Here, you will help characterize patient-derived T cell products using flow cytometry, as we search for early biomarkers and indications of an enhanced therapeutic response. This is a unique opportunity for career development where you will get the chance to work with patient samples in support of clinical-level programs, to gain immunological assay development experience, and to work in a fast-paced and highly collaborative environment.

Responsibilities:

• Establish/analyze cell-based functional assays to characterize patient samples, with a primary focus on flow cytometry staining and analysis.
• Follow and execute detailed in vitro assay standard protocols, under supervision if needed.
• Prepare data reports, properly document sample use, and maintain a detailed, accurate electronic laboratory notebook.
• Present results internally at team meetings, and contribute to scientific discussions.

 Requirements:

• B.S. or above in a biology-related science with 2+ years of lab based experience. Experience will determine level of role.
• Highly proficient in flow cytometry sample preparation and analysis, with demonstrated ability to follow complex protocols and an interest in developing new skills.
• Experience in, or strong interest to learn, deep phenotyping using Cytek Full Spectral Flow Cytometry.
• Detailed oriented with strong organizational and record-keeping skills.
• Basic data analysis skills with willingness to learn advanced analysis methods.
• Must be a strong team player with effective written/verbal communication skills.
• Proficiency using programs such as Excel, PowerPoint, GraphPad Prism (or similar), and FlowJo (or similar) for data entry, analysis, and presentations.
• This is a lab-based role, requiring the ability to work at a desk / lab bench, or on a computer, for prolonged periods of time.

At TCR² Therapeutics Inc, our inclusive and diverse team is passionate about curing cancer. We are a clinical-stage cell therapy company pioneering the development of novel T cell therapies by utilizing our TRuC platform. Our lead autologous cell product gavo-cel (TC-210) is being studied in a Phase 1/2 trial for treatment refractory mesothelin-expressing solid tumors. In addition, our emerging and dynamic oncology pipeline focuses on a series of next-generation enhancements, novel targets and an allogeneic platform which may further improve clinical outcomes and broaden patient access.

We are headquartered in Cambridge, Massachusetts with clinical manufacturing facilities in Stevenage, UK and Rockville, MD. This role will be based in Cambridge, MA. 

We are looking for a Scientist to join the Translational Science team and assist in functionally characterizing patient-derived clinical samples through in vitro tissue culture assays. You will report to a Senior Scientist in Translational Sciences, and work closely with other experienced scientists in the Translational Sciences and R&D Teams to support clinical-level programs. Here, you will help characterize clinical patient-derived T cell products, as we search for early biomarkers and indications of an enhanced therapeutic response. This is a unique opportunity for career development where you will get the chance to work with patient samples in support of clinical-level programs and to work in a fast-paced and highly collaborative environment.

Responsibilities:

• Establish/analyze cell-based functional assays to characterize patient samples. These assays will include (but are not limited to) flow cytometry, target cell killing, ELISA for cytokine production, and Nanostring transcriptional profiling.
• Follow and execute detailed in vitro assay standard protocols, and establish complex in vitro experiments.
• Prepare data reports, properly document clinical patient sample use, and maintain a detailed, accurate electronic laboratory notebook.
• Present results internally at team meetings, and contribute to scientific discussions.
• Evaluate emerging technologies and platforms to aid in defining and implementing the biomarker strategy in the context of early-stage clinical trials.
• Passage cell lines, handle primary cells, and other lab-based responsibilities to support Translational Sciences research.

 Requirements:

• B.S. or above in a biology-related science with 5+ years of relevant experience, or a PhD in a relevant field.
• Highly proficient in tissue culture, with demonstrated ability to follow complex tissue culture protocols, and a strong interest in developing new skills.
• Hands-on experience with assay development / qualification, preferably in assays of T cell function.
• Previous experience working with Incucyte systems a plus.
• Detailed oriented with strong organizational and record-keeping skills.
• Basic data analysis skills with willingness to learn advanced analysis methods.
• Must be a strong team player with effective written/verbal communication skills.
• Proficiency using programs such as Excel, PowerPoint, and GraphPad Prism (or similar) for data entry, analysis, and presentations.
• This is a lab-based role, requiring the ability to work at a desk / lab bench, or on a computer, for prolonged periods of time.

At TCR² Therapeutics Inc, our inclusive and diverse team is passionate about curing cancer. We are a clinical-stage cell therapy company pioneering the development of novel T cell therapies by utilizing our TRuC platform. Our lead autologous cell product gavo-cel (TC-210) is being studied in a Phase 1/2 trial for treatment refractory mesothelin-expressing solid tumors. In addition, our emerging and dynamic oncology pipeline focuses on a series of next-generation enhancements, novel targets and an allogeneic platform which may further improve clinical outcomes and broaden patient access.

We are headquartered in Cambridge, Massachusetts with clinical manufacturing facilities in Stevenage, UK and Rockville, MD. The ideal candidate will be based in Cambridge, MA, but this role is open for remote work with travel as needed. 

Responsibilities:

• Oversee efforts to identify and manage CROs for clinical biomarker assays; qualify/validate assays at CROs, oversee proper clinical sample testing and data analyses to support clinical program(s)
• Collaborate closely with the clinical operations and process development teams to monitor clinical sample collection and testing
• Review and approve the qualification/validation reports, study/lab manuals, data packages to support publication/presentation and/or submission to regulatory agencies
• Support generating hypothesis from clinical biomarker data for patient selection and TRuC T cell platform characterization for better patient outcome
• Continuously evaluate new technologies for clinical immunomonitoring and T cell functional characterization and develop new strategies for data analysis to maintain TCR2 on the cutting edge of clinical research

Requirements:

• MS, Ph.D. preferred, in immunology or similar discipline with 6+ years of directly relevant experience with at least 3+ years in the field of Translational Research and/or Immuno-Oncology is highly desirable
• Demonstrated experience leading clinical biomarker assay qualification at CROs, data analysis, and MoA/translational research for immuo-oncology/cell therapy clinical trials
• Experience with bioanalytical assays, including assays of T cell function, multi-parametric flow cytometry, mass cytometry, multiplex IHC/IF assays, real-time PCR and next generation sequence analysis
• Experience with CDx development is highly desirable
• Highly effective collaboration, written/verbal communication, and interpersonal skills

At TCR² Therapeutics Inc, our inclusive and diverse team is passionate about curing cancer. We are a clinical-stage cell therapy company pioneering the development of novel T cell therapies by utilizing our TRuC platform. Our lead autologous cell product gavo-cel (TC-210) is being studied in a Phase 1/2 trial for treatment refractory mesothelin-expressing solid tumors. In addition, our emerging and dynamic oncology pipeline focuses on a series of next-generation enhancements, novel targets and an allogeneic platform which may further improve clinical outcomes and broaden patient access. 

We are headquartered in Cambridge, Massachusetts with a clinical manufacturing facility in Rockville, MD. This role will be based in Cambridge, MA with hybrid flexibility. 

We are looking for a Sr. Scientist in Translational Research to work on the development of TCR²’s clinical programs and pipeline. You will report to our Director of Translational Science and work closely with a team of experienced Scientists analyzing patient samples and generating key biomarker data to determine correlations associated with clinical outcomes. This is a great opportunity for a talented Scientist working on Immunology research (or similar) to advance your career working on a clinical stage cell therapy programs as we continue to advance our pipeline.

Responsibilities:

• Manage CROs for timely and accurately running patient samples and delivering data to support clinical program(s)
• Collaborate closely with the clinical operations and manufacturing teams to monitor clinical sample collection and testing
• Review study/lab manuals and SOPs/ROPs for proper sample analysis and data collection.
• Assist generating and evaluating key data packages to support publication/presentation and/or submission to regulatory agencies
• Work as a key member to translational sciences team for defining and implementing data driven biomarker strategies to support correlative analysis for better patient outcome

Requirements:

• Ph.D.(preferred) or equivalent industry experience in immunology or similar discipline with 3+ years of directly relevant experience with at least 2+ years in an industry setting
• Experience in handling CROs to manage and analyze clinical samples is required; experience with Immuno-Oncology and/or cell therapies is highly desirable
• Experience leading the development and validation of biomarker assays using a broad range of technologies including ligand binding immunoassays, assays of T cell function, multi-parametric flow cytometry, mass cytometry, multiplex IHC/IF assays, real-time PCR and next generation sequence analysis
• Experience in complex data analysis is plus
• Experience in handling and managing clinical samples and biomarker assays is a plus 
• Highly effective collaboration, written/verbal communication, and interpersonal skills

At TCR² Therapeutics Inc, our inclusive and diverse team is passionate about curing cancer. We are a clinical-stage cell therapy company pioneering the development of novel T cell therapies by utilizing our TRuC platform. Our lead autologous cell product gavo-cel (TC-210) is being studied in a Phase 1/2 trial for treatment refractory mesothelin-expressing solid tumors. In addition, our emerging and dynamic oncology pipeline focuses on a series of next-generation enhancements, novel targets and an allogeneic platform which may further improve clinical outcomes and broaden patient access.

We are headquartered in Cambridge, Massachusetts with clinical manufacturing facilities in Stevenage, UK and Rockville, MD, which we can now call home for clinical & commercial manufacturing.

We are designing the state-of-the-art cell therapy facility in Rockville to utilize semi-automated and functionally closed systems which aim to provide cGMP manufacturing while optimizing the reliability of our cell therapy products and reducing manufacturing costs and vein-to-vein time. The flexible layout will allow production of gavo-cel and other emerging cell therapies in the TRuC-T cell pipeline.

The Rockville, Maryland site will support clinical and commercial production of gavo-cel with a capacity to treat several thousand cancer patients annually. This site is expected to accelerate TCR2’s commercial-scale manufacturing timelines with production anticipated in 2023. We will be hiring for positions throughout manufacturing, supply chain, and technical operations, as well as other functions.

If you are interested in joining us on this exciting journey please submit you information for future consideration and tailored job alerts. 

At TCR² Therapeutics Inc, our inclusive and diverse team is passionate about curing cancer. We are a clinical-stage cell therapy company pioneering the development of novel T cell therapies by utilizing our TRuC platform. Our lead autologous cell product gavo-cel (TC-210) is being studied in a Phase 1/2 trial for treatment refractory mesothelin-expressing solid tumors. In addition, our emerging and dynamic oncology pipeline focuses on a series of next-generation enhancements, novel targets and an allogeneic platform which may further improve clinical outcomes and broaden patient access. We are headquartered in Cambridge, Massachusetts with clinical manufacturing facilities in Stevenage, UK and Rockville, MD. 

Passion is at the heart of our research.

Our mission as a leader in the solid tumor field will always be to bring meaningful cellular therapies to cancer patients. With our positive interim gavo-cel data, our 2021 strategic goals are aimed at developing our emerging pipeline and further advancing our clinical programs – meaning we’re looking for someone passionate and driven like you to help us bring our therapies closer to reality as we rapidly grow. Being a part of the TCR2 team means more than just research and execution. Our efforts stretch beyond the lab with how we engage with the community with TCR2 Cares, where we support the cancer community and STEM education.

We will be hiring across all functions. Please submit your information to join our talent community for future consideration. 
 

At TCR² Therapeutics Inc, our inclusive and diverse team is passionate about curing cancer. We are a clinical-stage cell therapy company pioneering the development of novel T cell therapies by utilizing our TRuC platform. Our lead autologous cell product gavo-cel (TC-210) is being studied in a Phase 1/2 trial for treatment refractory mesothelin-expressing solid tumors. In addition, our emerging and dynamic oncology pipeline focuses on a series of next-generation enhancements, novel targets and an allogeneic platform which may further improve clinical outcomes and broaden patient access.

We are looking for a Research Associate/Sr. Research Associate to join our Immunology Research team and assist in screening TRuC candidates for our pipeline programs and contributing to the nomination of clinical lead. You will report to a Sr. Scientist in Immunology Research and work closely with a team of collegial scientists with diverse background. This is a unique opportunity for career development where you will be trained and involved in the pre-clinical steps and strategies of developing T cell therapies for treating solid tumors. A candidate with passion and attention to details will success in this role.

Responsibilities:

• Culture primary T cells (lentiviral transduction, TRuC T cell production)
• Execute cell-based in vitro assays (cytotoxicity, cytokine quantitation, activation, proliferation etc) by following detailed standard protocols.
• Participate in cell-based assay development and assay validation
• Analyze and interpretate experiment results under supervision
• Record accurate, complete, and timely data in laboratory notebooks/electronic notebook
• Present results in team meetings

Requirements:

• B.S./M.S. in Biology, Biotechnology, or a related field in the Life Sciences, with 1+ years research experience in academia or industry preferred,
• Strong aseptic technique and experience in mammalian cell culture,
• Exposure to flow cytometry, ELISA-based assays is a plus,
• Experience with developing cell therapies in Immuno-Oncology space is a strong plus.