Join Us

At TCR² Therapeutics Inc, our inclusive and diverse team is passionate about curing cancer. We are a clinical-stage cell therapy company pioneering the development of novel T cell therapies by utilizing our TRuC platform. Our lead autologous cell product gavo-cel (TC-210) is being studied in a Phase 1/2 trial for treatment refractory mesothelin-expressing solid tumors. In addition, our emerging and dynamic oncology pipeline focuses on a series of next-generation enhancements, novel targets and an allogeneic platform which may further improve clinical outcomes and broaden patient access. We are headquartered in Cambridge, Massachusetts with a manufacturing facility in Rockville, MD. This role can be remote with preferably on the East Coast.

We are growing our Clinical team and are seeking a Pharmacovigilance-Safety Physician to join our team. Reporting to our VP of Clinical Development Operations and directly supporting the CMO, you will provide medical expertise on safety and pharmacovigilance (PV) on a global level for our clinical programs. In this role you will oversee the review, analysis, and approval of Individual Case Safety Reports (ICSR) and Periodic Reports for investigational programs. Additionally, you will maintain active pharmacovigilance oversight including safety surveillance, benefit-risk assessment, signal detection, and will provide safety/medical input for review of risk management. In this role you will lead monthly safety reviews in collaboration with the clinical development & operations team and support PV compliance, regulatory inspections and audits for Pharmacovigilance. In tandem you will lead the preparation, facilitation, and documentation of safety governance meetings. This is an excellent time to join TCR² as we embark on pivotal stage for our gavo-cel program and expand our clinical pipeline.

Responsibilities:

• Review and communicate safety data- trending, signaling, and other safety-related issues originating from any source for the purposes of detecting and reviewing safety signals (e.g., change in frequency, nature, or severity of a safety-related issue)
• Review and proactively assess potential issues that could be lead to an urgent safety measure or restriction in clinical development (including, but not limited to, premature termination or suspension of a trial). In these cases, provide recommendations for review and approval
• Perform medical review for ICSRs and Analyses of Similar Events (AOSE) in the global safety database and perform weekly review of safety data to ensure no serious adverse event has been inadvertently missed
• Contribute to the safety section of protocol synopses, study protocols, INDs, DSURs, PBRERs, CSRs, BLA, etc.
• Develops risk management strategy for each drug candidate and contributes to development strategy, including elements that require strategic cross-functional input and alignment
• Ensures that DSPV timelines for medical review are followed by providing oversight and collaborating with the medical reviewers at the CRO
• Provides medical input to decisions related to any recalls of clinical supplies

Requirements:

• Board Certified (US) MD with 8+ years’ experience in drug safety and pharmacovigilance
• Extensive experience in Case Safety Reports (ICSR), safety surveillance, benefit-risk assessment, signal detection, and risk management strategies
• Strong understanding of the use of medical terminology and of drug-names in multiple nations and environments
• Proficiency in Argus, Microsoft Office Suite (Word, Excel) and databases.
• Knowledge of and experience in cell and gene therapy is a plus

At TCR² Therapeutics Inc, our inclusive and diverse team is passionate about curing cancer. We are a clinical-stage immunotherapy company pioneering the development of novel T cell therapies. Our two lead cell product candidates are being studied in Phase 1/2 trials: TC-210 and TC-510. Our research efforts focus on broadening our pipeline with a series of new targets and next-generation enhancements that may further improve clinical outcomes. We are headquartered in Cambridge, Massachusetts and have a clinical manufacturing facility in Rockville, Maryland. This role is located in Cambridge, MA.

We are growing and hiring a results-oriented Associate Director of Business Development and Strategy who will be collaborating with the Executive and leadership to source, evaluate, and manage strategic growth initiatives and Business Development opportunities. Reporting to the Chief Business and Strategy Officer you will be working on indication strategies and deal workstreams including due diligence, and communications. You are likely to have had significant strategy, consulting and/or transaction experience in Healthcare (ideally in oncology and cell therapy). This represents an excellent opportunity to join a growing organization in which you will have meaningful direct exposure and visibility to the most senior leadership to further your career.

Responsibilities:

• You will partner with the Chief Business and Strategy Officer, CEO and the Leadership Team as an advisor in developing long-range strategic plans for the company, translating strategy into tactical plans, and identifying and executing opportunities that bring those tactical plans to life
• You will evaluate the cell therapy and oncology industry landscapes to identify strategic opportunities and risks and to generate potential corporate development opportunities
• You will gather and analyze inputs from the competitive landscape, market research and comparable deal terms to create financial models for decision making
• You will propose licensing, acquisition and alliance opportunities which advance and enhance the company’s position in the marketplace. This will including building & maintaining a business development funnel of opportunities and industry comparables
• You will lead certain negotiations and partnering discussions, often without direct supervision, with the aim of attaining suitable terms and conditions with partners program(s) based upon commercial, scientific, and financial analysis.
• You will review term sheets, proposals and presentations for executing business development transactions
• You will work with the scientific and legal teams to evaluate business development and other strategic opportunities. You will help prepare and coordinate multifunctional assessments of external opportunities (i.e. patents, technological strength, development costs and timelines, competitiveness, economic potential, development and marketing risks …) and help negotiate contracts in close alignment with the legal department
• You will support alliance management, staying abreast of upcoming deliverables and ensuring that contractual obligations are met by effectively understanding and communicating such obligations both internally and externally
• You will often act as the prime point of contact for TCR2 and coordinate interfaces with senior management, the academic community, other biotech companies and pharmaceutical companies as well as venture capitalists and various industry consultants, investors and subject-matter experts

Requirements:

• Bachelor’s Degree in business or science discipline required. Advanced degree (MBA, MD, PhD, PharmD) strongly preferred
• 5+ years of search & evaluation, business development and/or corporate strategy experience in the biopharma/life sciences industry and/or consulting
• Proven understanding of the business development deal process, including deal structure development, due diligence, negotiations, and completing transactions, as well as evaluating pharmaceutical licensing opportunities
• Experience in licensing transactions for cell therapy and/or oncology technologies or early-stage products is a plus
• Strong financial modeling capabilities, including typical valuation methods and understanding of financial fundamentals required
• Oncology, cell therapy, and/or immunology expertise a plus
• Results-oriented with solid analytical skills required to understand and challenge inputs into evaluations and build business cases
• Demonstrated ability to build rapport with and influence therapeutic and functional area leaders. Ability to build consensus between multiple internal/external partners, functions, and stakeholders
• Superb project management skills; attention to detail, strong organizational and follow-up skills
• Strong scientific/medical aptitude; ability to articulate complex scientific/medical concepts in a clear and concise manner and maintain credibility with internal and external scientific and business experts
• Entrepreneurial self-starter who thrives in a dynamic, fast-paced environment and “roll-up your sleeves” culture

At TCR² Therapeutics Inc, our inclusive and diverse team is passionate about curing cancer. We are a clinical-stage cell therapy company pioneering the development of novel T cell therapies by utilizing our TRuC platform. Our lead autologous cell product gavo-cel (TC-210) is being studied in a Phase 1/2 trial for treatment refractory mesothelin-expressing solid tumors. In addition, our emerging and dynamic oncology pipeline focuses on a series of next-generation enhancements, novel targets and an allogeneic platform which may further improve clinical outcomes and broaden patient access.

We are headquartered in Cambridge, Massachusetts with a manufacturing facility in Rockville, MD. This global role will be based in the Cambridge.

We are seeking an Executive Assistant to join our team and provide critical support to C-Suite and senior leaders in various departments within TCR2. You will work closely with our administrative team members as well as coordinate and communicate with outside parties. We are looking for someone who is highly professional, solutions oriented, and is accustomed to working with information that is both critical and confidential. This is a great time to join a growing and collaborative company. You will have the opportunity to extend your scope of experience through company-wide initiatives and have a direct impact on the culture of the company.

Responsibilities:

• Forward-facing professional interactions with internal and external stakeholders
• Proactively manage calendars and provide scheduling support for assigned executives including coordination across varying time-zones
• Coordinate internal/external meetings with efficiency and detail; communicating clearly to explain conflicts and need to re-prioritize
• Prepare, edit distribute and archive presentation-quality documents (Microsoft Office Suite)
• Team coordination and preparation for internal and external meetings
• Maintain and order office supplies and equipment
• Follow internal process for information dissemination and confidentiality
• Event planning assistance- ordering catering, setup and breakdown of company and board member events
• Manage travel arrangements (domestic/international)
• Manage standing meetings and off sites with leaders’ teams as required
• Manage all aspects of conference attendance – registration, travel, pre-attendance prep meetings.
• Analyze needs and problems, and determine approach and priority in collaboration with senior leaders, their teams and administrative colleagues across functions
• Prepare expense reports and approve online expense, time off submittals and Workday actions as assigned
• Provided Cambridge site support as needed (events, coordination of meetings, administrative tasks, etc.)

Requirements:

• 2+ years of relevant experience providing senior leader level administrative support in a corporate environment; a degree is desirable, but not required
• Proven ability to take initiative, determine priorities and exercise good judgment
• Confidence with significant calendar management
• Ability to recognize opportunities & challenges, apply analytical and creative thinking to address issues or find innovative solutions and see it through to completion by taking ownership and accountability
• Provide support outside of regular business hours and across time-zones
• Professional confidence in own ability and demonstrated experience working through complex situations/issues
• Demonstrated ability to work on multiple projects simultaneously leveraging strong organizational skills and attention to detail, recognizing value and impact of the results
• Proficiency in Microsoft Office
• Demonstrated ability to take on projects as required
• Experience in a high growth, fast paced corporate environment preferred
• Knowledge of biopharmaceutical industry a plus

At TCR² Therapeutics Inc, our inclusive and diverse team is passionate about curing cancer. We are a clinical-stage cell therapy company pioneering the development of novel T cell therapies by utilizing our TRuC platform. Our lead autologous cell product gavo-cel (TC-210) is being studied in a Phase 1/2 trial for treatment refractory mesothelin-expressing solid tumors. In addition, our emerging and dynamic oncology pipeline focuses on a series of next-generation enhancements, novel targets and an allogeneic platform which may further improve clinical outcomes and broaden patient access.

We are seeking a Supply Chain Logistics Coordinator to support our clinical trials and ensure patients can be dosed on time with a high-quality product.  The Logistics Coordinator will be a contributing member of study teams and routinely interacts with the Clinical Operations, Manufacturing and Quality departments to ensure manufacturing and capacity demand planning align to meet the clinical operation’s needs.  You will be responsible for maintaining a detailed calendar of product operations and may lead cross-functional team meetings to ensure logistics, manufacturing, and clinical teams are aligned to allow for on-time dosing of every patient.  You will also navigate product operations and enter, track, and manage the operational shipping requirements while liaising with both internal and external customers/vendors. This is an excellent opportunity to join a growing company as we expand our clinical trials.

Responsibilities:

• Collaborate with the Clinical, Manufacturing and Quality personnel to coordinate shipping activities
• Coordinate all aspects of study participant sample collection including apheresis, shipping, processing, manufacturing and return of investigational product back to the clinical trial sites to successfully meet ship dates
• Provide shipping status and order visibility information as required to both internal and external clients, monitoring shipping information, closing of shipped orders, order status
• Provide routing information to ensure that delivery times and locations are coordinated
• Prepare accurate bills of lading and packing slips, arranging for necessary shipping documentation, and contacting customs officials to effect release of shipments
• Communicate with freight forwarders, third-party warehousing, and transportation companies
• Assist, as necessary, the Laboratory and Facilities with shipping activities
• Proactively identifies potential study issues/risks and recommends/implements solutions
• Participate in the development, review and implementation of departmental SOPs and processes
• Examine invoices and shipping manifests for conformity tariff and customs regulations and report issues to Clinical Operations Team 
• Conduct analysis on shipping quality incidents as needed
• Prepare metrics and updates for management as assigned

Requirements:

• Bachelor’s degree Preferred
• 2+ years of relevant logistical experience, which includes 1+ years within the Biotech/Pharmaceutical Industry. Cell/Gene Therapy experience preferred
• Experience in a GMP environment required
• Experience working with CMOs desirable
• Proactive in approach to work, identifying potential issues well in advance and bringing them to the attention of appropriate personnel for resolution
• Excellent MS Office and MS Project skills
• Ability to work on multiple projects simultaneously
• Ability to work effectively in a collaborative team environment where results are achieved through influence and the incorporation of multiple points of view
• Self-motivated, detailed oriented and energized in approach to work
• Excellent organizational skills, sufficient to multi-task in an extremely fast-paced environment with changing priorities

At TCR² Therapeutics Inc, our inclusive and diverse team is passionate about curing cancer. We are a clinical-stage cell therapy company pioneering the development of novel T cell therapies by utilizing our TRuC platform. Our lead autologous cell product gavo-cel (TC-210) is being studied in a Phase 1/2 trial for treatment refractory mesothelin-expressing solid tumors. In addition, our emerging and dynamic oncology pipeline focuses on a series of next-generation enhancements, novel targets and an allogeneic platform which may further improve clinical outcomes and broaden patient access. We are headquartered in Cambridge, Massachusetts with a manufacturing facility in Rockville, MD. This role is based in Cambridge, Massachusetts, and relocation is available if desired.

We are looking for a Process Engineer to join our growing Manufacturing Sciences and Technologies (MSAT) team. You will report to our Associate Director of MSAT and work closely with the External Manufacturing, Process Development, Analytical Development, Regulatory, Quality Control, and Quality Assurance teams.

Responsibilities:

• Maintain and analyze manufacturing process data to lead continuous process monitoring efforts.
• Lead deviation investigations for MSAT to provide technical assessments to the Quality team.
• Oversee TRuC T cell manufacturing, as a member of matrixed teams,  across our network of manufacturing sites to enable timely and successful manufacture and release of drug products for ongoing clinical trials and new programs.
• Support technology transfers of our existing or new manufacturing processes to new or existing manufacturing teams.
• Utilize established business processes and cross-functional relationships with internal/external partners.
• Provide technical support to the manufacturing sites for process or equipment related issues during manufacturing and ensure cross-functional engagement internally.
• Other duties as assigned.

Responsibilities:

• Bachelors’ Degree in Engineering, Life Sciences or related field. Graduate degree a plus.
• 5+ years relevant experience in life sciences manufacturing, MSAT,  process development, or similar and experience in managing external partners.
• Experience with technology transfer, technical support, and process characterization/validation strongly preferred.
• Experience in biologics or cell/gene therapy preferred.
• Knowledge of GMP regulations and a commitment to operational excellence.
• Proven strong and visible leadership with the ability and influence other functions within the organization
• Ability to work multi-functionally across a customer-centric organization
• 10% domestic travel anticipated
• Desire to work in a fast-paced growing company!

At TCR² Therapeutics Inc, our inclusive and diverse team is passionate about curing cancer. We are a clinical-stage cell therapy company pioneering the development of novel T cell therapies by utilizing our TRuC platform. Our lead autologous cell product gavo-cel (TC-210) is being studied in a Phase 1/2 trial for treatment refractory mesothelin-expressing solid tumors. In addition, our emerging and dynamic oncology pipeline focuses on a series of next-generation enhancements, novel targets and an allogeneic platform which may further improve clinical outcomes and broaden patient access.

We are headquartered in Cambridge, Massachusetts with a clinical manufacturing facility in Rockville, MD. This role will be based in Cambridge, MA. 

We are looking for an Associate Scientist to develop novel molecular assays to detect and quantify impurities in our drug product and process. This position will also participate in T Cell product characterization studies. You will report to our Scientist, Analytical Development and work closely with the T Cell Process Development team.

Your primary responsibilities will include research and development of assays to detect process-related impurities during the T Cell production process, and assay qualification. Authoring work instructions, protocols, reports, and presentations will be critical in this role. Additional activities could include improvement of existing assays and routine testing of samples throughout the T Cell production process, including the final product. This position represents an excellent opportunity for career development, working closely with experienced scientists in a fast-paced and highly collaborative environment.

Responsibilities:

• Develop new analytical methods in-house and manage method development and/or custom reagent development at contract research organizations as necessary.
• Execute a variety of analytical methods, including cell-based assays, ELISAs, and flow cytometry.
• Analyze data, document results, and write corresponding technical reports for product characterization studies.
• Write protocols and reports for internal and/or regulatory use.
• Work closely and effectively with CMC stakeholders, including Process Development and Quality.
• This is a hands-on position requiring execution of laboratory experiments.

Requirements:

• M.S. in biochemistry, chemical engineering, or related discipline with 4+ years relevant industry experience, or B.S. with 5+ years relevant industry experience.
• Industry experience is required for this position.
• Experience with analytical assays required, with emphasis on cell and plate-based assays.
• Strong technical writing skills with industry experience writing technical protocols, reports, and procedures is required.
• Experience with flow cytometry, mammalian cell culture, and/or primary human cells a plus.
• Experience with statistical analysis software, e.g. JMP, is a plus.
• Outstanding critical thinking and organizational skills, leadership, and attention to detail.
• Team-based candidate interested in a fast-paced, exciting, start-up environment!

At TCR² Therapeutics Inc, our inclusive and diverse team is passionate about curing cancer. We are a clinical-stage cell therapy company pioneering the development of novel T cell therapies by utilizing our TRuC platform. Our lead autologous cell product gavo-cel (TC-210) is being studied in a Phase 1/2 trial for treatment refractory mesothelin-expressing solid tumors. In addition, our emerging and dynamic oncology pipeline focuses on a series of next-generation enhancements, novel targets and an allogeneic platform which may further improve clinical outcomes and broaden patient access. We are headquartered in Cambridge, Massachusetts with a clinical manufacturing facility in Rockville, MD

We are looking for a Principal Scientist/Associate Director to drive method development for our TRuC T Cells. You will report to our head of Analytical Development and work closely with the Regulatory and T Cell Process Development teams.

The successful candidate will join the Analytical Development Team to drive method development for T Cell release testing and characterization. Primary responsibilities include design of studies for method development and qualification, authorship of technical protocols and reports, coordination of testing, and troubleshooting as needed. Additional activities include support of method transfer to internal and external manufacturing partners. The position represents an excellent opportunity for career development, working closely with experienced scientists in a fast-paced and highly collaborative environment.

Responsibilities:

• Manage a team focused on T Cell method development, including provision of mentorship, guideance, and hiring of new team members.
• Provide relevant updates to CMC leadership on T Cell analytical methods, and contribute to CMC strategy for release testing and characterization of T Cell drug product.
• Manage execution of analytical methods to support assay development and product understanding for lentiviral vectors and T Cells.
• Design experiments, assist with data analysis, interpretation and troubleshooting and write corresponding technical reports for method development and product understanding studies.
• Coordinate and schedule routine testing for junior group members and prioritize work to meet timelines.
• Write protocols and operating procedures for technology transfer and internal use.
• Work closely and effectively with our internal manufacturing group and/or CMOs for technology transfer and support.
• This position requires some in-person attendance for oversight of laboratory work, troubleshooting, and team leadership. 

Requirements:

• Ph.D. in biochemistry, chemical engineering, or related discipline with at least 4 years of relevant industry experience, M.S. with 10+ years relevant industry experience, or B.S. with 12+ years relevant industry experience.
• Strong technical writing skills with industry experience writing technical protocols, reports, and procedures required.
• Experience with analytical assay development required, with emphasis on flow cytometry and plate-based bioassays.
• Experience with method qualification and/or validation a plus.
• Experience with flow cytometry and cell-based assays required. Experience with primary T cells a plus.
• Outstanding critical thinking and organizational skills, leadership, and attention to detail
• Team-based candidate interested in a fast-paced, exciting, start-up environment!

At TCR² Therapeutics Inc, our inclusive and diverse team is passionate about curing cancer. We are a clinical-stage cell therapy company pioneering the development of novel T cell therapies by utilizing our TRuC platform. Our lead autologous cell product gavo-cel (TC-210) is being studied in a Phase 1/2 trial for treatment refractory mesothelin-expressing solid tumors. In addition, our emerging and dynamic oncology pipeline focuses on a series of next-generation enhancements, novel targets and an allogeneic platform which may further improve clinical outcomes and broaden patient access.

We are headquartered in Cambridge, Massachusetts with a clinical manufacturing facility in Rockville, MD

We are looking for an Associate Scientist to perform testing of cellular drug products using complex bioassays and participate in T Cell product characterization studies. You will report to our Principal Scientist, Analytical Development and work closely with the Regulatory and T Cell Process Development teams.

Your primary responsibilities will include testing of manufactured T Cells, and characterization of engineered T Cells for product and attribute understanding. Additional activities could include evaluation of new technologies, improving existing assays, and authorship of regulatory documents. The position represents an excellent opportunity for career development, working closely with experienced scientists in a fast-paced and highly collaborative environment.

Responsibilities:

• Execute a variety of analytical methods, including cell based assays, ELISAs, and flow cytometry.
• Analyze data, document results, and write corresponding technical reports for product characterization studies.
• Write protocols and reports for internal and/or regulatory use.
• Work closely and effectively with CMC stakeholders, including Process Development, Regulatory, and Quality.
• This is a hands-on position requiring execution of laboratory experiments.

Requirements:

• M.S. in biochemistry, chemical engineering, or related discipline with 4+ years relevant industry experience, or B.S. with 5+ years relevant industry experience.
• Industry experience is required for this position.
• Experience with analytical assays required, with emphasis on cell and plate-based assays.
• Experience with flow cytometry, mammalian cell culture, and/or primary human cells a plus.
• Strong technical writing skills with industry experience writing technical protocols, reports, and procedures is required.
• Outstanding critical thinking and organizational skills, leadership, and attention to detail.
• Team-based candidate interested in a fast-paced, exciting, start-up environment!

At TCR² Therapeutics Inc, our inclusive and diverse team is passionate about curing cancer. We are a clinical-stage cell therapy company pioneering the development of novel T cell therapies by utilizing our TRuC platform. Our lead autologous cell product gavo-cel (TC-210) is being studied in a Phase 1/2 trial for treatment refractory mesothelin-expressing solid tumors. In addition, our emerging and dynamic oncology pipeline focuses on a series of next-generation enhancements, novel targets and an allogeneic platform which may further improve clinical outcomes and broaden patient access.

We are headquartered in Cambridge, Massachusetts with a clinical manufacturing facility in Rockville, MD. 

We are looking for a Research Associate/Sr. Research Associate to join the T Cell Process Development team to work on cutting edge TRuC T cell manufacturing process, and to support regulatory filings. You will report to our Senior Scientist, T Cell Process Development and work closely with the Analytical Development group and other teams as needed. This is an excellent opportunity for career development, working closely with experienced scientists in a fast-paced and highly collaborative environment to support the production and in vitro characterizations of novel autologous and allogeneic TRuC-T cells programs.

Responsibilities:

• Perform T cell isolation, enrichment, activation, transduction, expansion and cryopreservation utilizing functionally closed cell systems
• Perform in-vitro cellular assays involving flow cytometric, molecular and functional characterization of genetically engineered primary T cells
• Collaborate with the Analytical Development group in improving primary T-cells characterization
• Contribute to the development and production of TRuC™ T-cells for various pipeline programs and in-vivo animal studies
• Analyze results and document scientific results for IND enabling studies

Requirements:

• B.S./M.S. degree in immunology, cell biology or similar discipline with 2+ years of experience in biotech and/or Pharma
• Experience in analytical assay execution and development, particularly cell based toxicity assays is required and flow cytometry, ELISA, PCR is preferred 
• Experience working with lentiviral and transduction of human T cells along with functionally closed systems are highly desirable. If no experience this is an opportunity to learn!
• Excellent attention to detail and problem-solving skills, ability to analyze and interpret data.
• Must be a highly effective collaborator with strong written/verbal communication and interpersonal skills

At TCR² Therapeutics Inc, our inclusive and diverse team is passionate about curing cancer. We are a clinical-stage cell therapy company pioneering the development of novel T cell therapies by utilizing our TRuC platform. Our lead autologous cell product gavo-cel (TC-210) is being studied in a Phase 1/2 trial for treatment refractory mesothelin-expressing solid tumors. In addition, our emerging and dynamic oncology pipeline focuses on a series of next-generation enhancements, novel targets and an allogeneic platform which may further improve clinical outcomes and broaden patient access.

We are headquartered in Cambridge, Massachusetts with a clinical manufacturing facility in Rockville, MD. 

We are looking for a Research Associate to join the T Cell Process Development team to work on cutting edge TRuC T cell manufacturing process, and to support regulatory filings. You will report to our Scientist, T Cell Process Development and work closely with the Analytical Development group and other teams as needed. This is an excellent opportunity for career development, working closely with experienced scientists in a fast-paced and highly collaborative environment to support the production and in vitro characterizations of novel autologous and allogeneic TRuC-T cells programs.

Responsibilities:

• Perform T cell isolation, enrichment, activation, transduction, expansion and cryopreservation utilizing functionally closed cell systems
• Perform in-vitro cellular assays involving flow cytometric, molecular and functional characterization of genetically engineered primary T cells
• Collaborate with the Analytical Development group in improving primary T-cells characterization
• Contribute to the development and production of TRuC™ T-cells for various pipeline programs and in-vivo animal studies
• Analyze results and document scientific results for IND enabling studies

Requirements:

• B.S./M.S. degree in immunology, cell biology or similar discipline with 0-2 years of experience in biotech and/or Pharma
• Experience in analytical assay execution and development, particularly cell based toxicity assays is required and flow cytometry, ELISA, PCR is preferred 
• Experience working with lentiviral and transduction of human T cells along with functionally closed systems are highly desirable. If no experience this is an opportunity to learn!
• Excellent attention to detail and problem-solving skills, ability to analyze and interpret data.
• Must be a highly effective collaborator with strong written/verbal communication and interpersonal skills

At TCR² Therapeutics Inc, our inclusive and diverse team is passionate about curing cancer. We are a clinical-stage immunotherapy company pioneering the development of novel T cell therapies. Our two lead cell product candidates are being studied in Phase 1/2 trials: TC-210 for solid tumors and TC-110 for hematological malignancies. Our research efforts focus on broadening our pipeline with a series of next-generation enhancements that may further improve clinical outcomes. We are headquartered in Cambridge, Massachusetts. 

We are looking for a Senior Scientist to drive deep characterization and method development for our TRuC T Cells. You will report to our head of T Cell Method Development and work closely with the Translational Research, T Cell Process Development, Quality Control, and Regulatory teams. 

The successful candidate will join the Analytical Development team to drive method development for T Cell characterization. Primary responsibilities include development of methods for TRuC T cell characterization, with a focus on flow cytometry, and training/mentorship of junior team members. Additional activities include evaluation of new technologies, partnership with internal and/or external testing labs, and writing of technical documents. The position represents an excellent opportunity for career development, working closely with experienced scientists in a fast-paced and highly collaborative environment. 

Responsibilities: 

• Develop and optimize flow cytometry tests for engineered TRuC T Cells and starting material. 

• Collaborate within analytical development and cross-functionally for evaluation and development of additional techniques for characterization of engineered TRuC T Cells. 

• Evaluate new technologies for release and characterization testing. 

• Develop additional techniques to further understanding of engineered T Cell characteristics. 

• Design experiments, assist with data analysis, interpretation and troubleshooting and write corresponding technical reports for method development and product understanding studies. 

• Write protocols and operating procedures for internal use and/or technology transfer. 

• Provide mentorship and training for junior team members, and coordinate and prioritize work to meet timelines.  

• This is a hands-on position requiring both execution and oversight of laboratory work. 

Requirements: 

• Ph.D. in biochemistry, chemical engineering, or related discipline with at least 2 years of relevant industry experience, M.S. with 8+ years relevant industry experience, or B.S. with 10+ years relevant industry experience. 

• Strong technical writing skills with industry experience writing technical protocols, reports, and procedures required. 

• Experience with development of flow cytometry methods required. 

• Experience with engineered cell therapies in an industry or academic environment required. 

• Experience with additional analytical techniques, including cell-based assays, PCR, ELISAs, and/or gel electrophoresis a plus. 

• Outstanding critical thinking and organizational skills, leadership, and attention to detail 

• Team-based candidate interested in a fast-paced, exciting, start-up environment! 

At TCR² Therapeutics Inc, our inclusive and diverse team is passionate about curing cancer. We are a clinical-stage cell therapy company pioneering the development of novel T cell therapies by utilizing our TRuC platform. Our lead autologous cell product gavo-cel (TC-210) is being studied in a Phase 1/2 trial for treatment refractory mesothelin-expressing solid tumors. In addition, our emerging and dynamic oncology pipeline focuses on a series of next-generation enhancements, novel targets and an allogeneic platform which may further improve clinical outcomes and broaden patient access. We are headquartered in Cambridge, Massachusetts with a clinical manufacturing facility in Rockville, MD. This role will be based in Cambridge, MA. 

We are looking for a Scientist to develop and optimize a function potency assay. This will focus on a cell-based assay with flow cytometry and ELISA-based outputs that will be used for characterization of T cell drug product and LVV potency. You will report to a Principal Scientist, Analytical Development and work closely with the Regulatory, T Cell, and Vector Process Development teams.  

Your primary responsibilities will include development and optimization of a functional potency assay, authorship of technical protocols and reports, and execution of experiments. Additional activities include method optimization and method qualification. This position represents an excellent opportunity for career development, working closely with experienced scientists in a fast-paced and highly collaborative environment.  

Responsibilities:  

• Execute a variety of analytical methods, including cell-based assays, ELISAs, and flow cytometry.  

• Design experiments, analyze data, and author corresponding technical reports for product characterization studies and assay qualification studies. 

• Write protocols and reports for internal and/or regulatory use. 

• Work closely and effectively with CMC stakeholders, including Process Development, Regulatory, and Quality. 

• This is a hands-on position requiring execution of laboratory experiments. 

Requirements: 

• M.S. in biochemistry, chemical engineering, or related discipline with 4+ years relevant industry experience, or B.S. with 5+ years relevant industry experience.  

• Industry experience is required for this position.  

• Experience with analytical assays required, with emphasis on cell and plate-based assays.  

• Strong technical writing skills with industry experience writing technical protocols, reports, and procedures is required.  

• Outstanding critical thinking and organizational skills, leadership, and attention to detail.  

• Team-based candidate interested in a fast-paced, exciting, start-up environment. 

At TCR² Therapeutics Inc, our inclusive and diverse team is passionate about curing cancer. We are a clinical-stage cell therapy company pioneering the development of novel T cell therapies by utilizing our TRuC platform. Our lead autologous cell product gavo-cel (TC-210) is being studied in a Phase 1/2 trial for treatment refractory mesothelin-expressing solid tumors. In addition, our emerging and dynamic oncology pipeline focuses on a series of next-generation enhancements, novel targets and an allogeneic platform which may further improve clinical outcomes and broaden patient access. We are headquartered in Cambridge, Massachusetts with a clinical manufacturing facility in Rockville, MD. This role will be based in Cambridge, MA. 

We are looking for a Scientist/Associate Scientist to optimize assays and lead tech transfer of key platform tests for final platform development efforts. Assays will focus on residual impurities such as pDNA, gDNA, HCP, etc. You will report to a Principal Scientist, Analytical Development and work closely with the Vector Process Development (VPD) Group.  

Your primary responsibilities will include optimization and tech transfer of assays in support of key VPD platform tests, design of studies for product attribute understanding, authorship of technical protocols and reports, and execution of experiments. You will also be part of internal and external transfers and collaborations. Will need to manage external CMO/CTO. Additional activities include method optimization and method qualification. This position represents an excellent opportunity for career development, working closely with experienced scientists in a fast-paced and highly collaborative environment.  

Responsibilities:  

• Execute a variety of analytical methods, including cell and plate-based assays, qPCR/ddPCR, and ELISAs 

• Design experiments, analyze data, and author corresponding technical reports for product characterization studies and assay qualification studies. 

• Write protocols and reports for internal and/or regulatory use. 

• Work closely and effectively with CMC stakeholders, including Process Development, Regulatory, and Quality. 

• This is a hands-on position requiring execution of laboratory experiments. 

Requirements: 

• M.S. in biochemistry, chemical engineering, or related discipline with 4+ years relevant industry experience, or B.S. with 5+ years relevant industry experience.  

• Industry experience is required for this position.  

• Experience with analytical assays required, with emphasis on cell and plate-based assays.  

• Strong technical writing skills with industry experience writing technical protocols, reports, and procedures is required.  

• Outstanding critical thinking and organizational skills, leadership, and attention to detail.  

• Team-based candidate interested in a fast-paced, exciting, start-up environment. 

At TCR² Therapeutics Inc, our inclusive and diverse team is passionate about curing cancer. We are a clinical-stage cell therapy company pioneering the development of novel T cell therapies by utilizing our TRuC platform. Our lead autologous cell product gavo-cel (TC-210) is being studied in a Phase 1/2 trial for treatment refractory mesothelin-expressing solid tumors. In addition, our emerging and dynamic oncology pipeline focuses on a series of next-generation enhancements, novel targets and an allogeneic platform which may further improve clinical outcomes and broaden patient access.

We are headquartered in Cambridge, Massachusetts with a clinical manufacturing facility in Rockville, MD. This position will be based in Cambridge, MA. 

We are looking for a Director of Cell Process Development. Reporting into our Vice President this will be a key leadership position within the company and an excellent opportunity for career development in a fast-paced and highly collaborative environment.  In this role you will work closely with the manufacturing, clinical and discovery teams through all stages of clinical development. 

You will be expected to play an integral role in the development and translation of the TRuC T cell platform. Specifically, working with the Technical Operations teams to strategize and manage the technology transfer and characterization processes to advance our platform towards clinical and commercial stages as well as support CMC activities.You will be expected to grow and manage a cutting-edge team that will catalyze the growth of the TCR² platform.

Responsibilities:

• Lead a dynamic and highly skilled process development team. Define and build out an effective team to oversee process development/transfer and in-house manufacturing oversight through personal leadership and direct reports
• Lead late-stage process development strategy and execution for gene-edited ex-vivo cell therapy products based on TRuC T cells for transition of clinical-stage candidates towards commercialization.
• Manage technology transfer strategy, protocol development and establish acceptance specifications for transition to GMP facilities for all CMC activities with ability to travel for in-person and in-plant interactions.
• Provide technical support to the clinical manufacturing programs.
• Author and review CMC content for IND submissions, amendments and ultimately BLA filing(s).
• Collaborate with other departments to identify efficiencies needed to meet critical corporate objectives, encompassing the area engineered T cell manufacturing.
• Define departmental goals and manage experimental programs to align with corporate goals.
• Determine and manage departmental yearly budget.
• Influence through effective communication, respectful challenge, and persuasion across the organization.

Requirements:

• M.S. or Ph.D. in Cell Biology, Immunology or Virology is preferred.
• M.S. with 8+ years or Ph.D. with 6+ years of relevant industry experience. 
• Demonstrated skills in building teams and executing on projects in a timely manner.
• Proven track record in leading pre-clinical stage programs and cross-functional teams through to successful INDs.
• Biotech experience is strongly preferred with a focus on cell and gene therapy, virology or biologics.
• Previous experience with development and manufacture of engineered T cells is strongly preferred.
• Ability to adapt and thrive in a dynamic and entrepreneurial clinical-stage environment.
• Superior personnel management and organizational skills.
• A scientifically motivated self-starter, capable of independently conceiving, conducting, and critically analyzing his/her own work with minimal supervision.
• A strong presenter and communicator, with the ability to work in a fast-paced and team-oriented environment.

At TCR² Therapeutics Inc, our inclusive and diverse team is passionate about curing cancer. We are a clinical-stage immunotherapy company pioneering the development of novel T cell therapies. Our two lead cell product candidates are being studied in Phase 1/2 trials: TC-210 for solid tumors and TC-110 for hematological malignancies. Our research efforts focus on broadening our pipeline with a series of next-generation enhancements that may further improve clinical outcomes. We are headquartered in Cambridge, Massachusetts and this role is located in Cambridge, MA.

We are growing and hiring an Associate Scientist to join our Process Development team. You will work with the rest of the team for the purification of lentiviral vectors, and development of a robust and scalable manufacturing process.

This role is a unique opportunity for you to advance your career development, actively working with a close team in a fast-paced and highly collaborative environment.

Responsibilities: 

• Utilize skills to help develop, optimize, and scale downstream purification operations for our viral vector process.
• Lead key projects through both independent execution and collaboration with other team members.
• Generate data through well-defined and executed design of experiment studies, while organizing and prioritizing work to meet timelines. 
• Write protocols and reports to support executed work and technology transfers from process development to manufacturing.
• Present executed work at scientific presentations and meetings.

Requirements: 

• BS or MS in chemical engineering, biochemical engineering, or related discipline and at least 3-4 years of relevant industry experience.
• Technical experience with purification applications is required, including solid technical knowledge and hands on experience specifically with TFF and sterile filtration operations. 
• Additional knowledge with formulation and fill/finish activities is preferred.
• Experience with tech transfer and GMP manufacturing systems is preferred. 
• Outstanding critical thinking and organizational skills, leadership, and attention to detail 
• Team-based candidate interested in a fast-paced, exciting, start-up environment! 

At TCR² Therapeutics Inc, our inclusive and diverse team is passionate about curing cancer. We are a clinical-stage cell therapy company pioneering the development of novel T cell therapies by utilizing our TRuC platform. Our lead autologous cell product gavo-cel (TC-210) is being studied in a Phase 1/2 trial for treatment refractory mesothelin-expressing solid tumors. In addition, our emerging and dynamic oncology pipeline focuses on a series of next-generation enhancements, novel targets and an allogeneic platform which may further improve clinical outcomes and broaden patient access.

We are headquartered in Cambridge, Massachusetts with a clinical manufacturing facility in Rockville, MD. 

We are looking for a Sr. Research Associate to join the T Cell Process Development team to work on cutting edge TRuC T cell manufacturing process, and to support regulatory filings. You will report to our Senior Scientist, T Cell Process Development and work closely with the Analytical Development group and other teams as needed. This is an excellent opportunity for career development, working closely with experienced scientists in a fast-paced and highly collaborative environment to support the production and in vitro characterizations of novel autologous and allogeneic TRuC-T cells programs.

Responsibilities:

• Perform T cell isolation, enrichment, activation, transduction, expansion and cryopreservation utilizing functionally closed cell systems
• Perform in-vitro cellular assays involving flow cytometric, molecular and functional characterization of genetically engineered primary T cells
• Collaborate with the Analytical Development group in improving primary T-cells characterization
• Contribute to the development and production of TRuC™ T-cells for various pipeline programs and in-vivo animal studies
• Analyze results and document scientific results for IND enabling studies

Requirements:

• B.S./M.S. degree in immunology, cell biology or similar discipline with 2+ years of experience in biotech and/or Pharma
• Experience in analytical assay execution and development, particularly cell-based toxicity assays is required and flow cytometry, ELISA, is preferred 
• Experience working with lentiviral and transduction of human T cells along with functionally closed systems are highly desirable. If no experience this is an opportunity to learn!
• Experience with statistical analysis methods such as JMP, Prism, Flojo, DoE is preferred

At TCR² Therapeutics Inc, our inclusive and diverse team is passionate about curing cancer. We are a clinical-stage cell therapy company pioneering the development of novel T cell therapies by utilizing our TRuC platform. Our lead autologous cell product gavo-cel (TC-210) is being studied in a Phase 1/2 trial for treatment refractory mesothelin-expressing solid tumors. In addition, our emerging and dynamic oncology pipeline focuses on a series of next-generation enhancements, novel targets and an allogeneic platform which may further improve clinical outcomes and broaden patient access. We are headquartered in Cambridge, Massachusetts with a clinical manufacturing facility in Rockville, MD

We are growing and hiring a Research Associate/Senior Research Associate (Dependent on experience) to join our Process Development team. You will report to a Senior Scientist on the team and work with the rest of the team for the purification of lentiviral vectors, and development of a robust and scalable manufacturing process.

This role is a unique opportunity for you learn and advance your career development actively working with a close team in a fast-paced and highly collaborative environment.

Responsibilities: 

• Utilize skills to help develop, optimize, and scale downstream purification operations for our viral vector process
• Lead key projects through both independent execution and collaboration with other team members
• Generate data through well-defined and executed design of experiment studies, while organizing and prioritizing work to meet timelines 
• Write protocols and reports to support executed work and technology transfers from process development to manufacturing
• Present executed work at scientific presentations and meetings

Requirements: 

• BS or MS in chemical engineering, biochemical engineering, or related discipline and at least 3 years of industry experience
• Technical experience with purification applications is required, including solid foundational knowledge of filtration and chromatography applications
• Additional experience with formulation and fill/finish activities is a plus
• Experience with tech transfer and GMP manufacturing systems is preferred
• Outstanding critical thinking and organizational skills, leadership, and attention to detail 
• Team-based candidate interested in a fast-paced, exciting, start-up environment! 

At TCR² Therapeutics Inc, our inclusive and diverse team is passionate about curing cancer. We are a clinical-stage cell therapy company pioneering the development of novel T cell therapies by utilizing our TRuC platform. Our lead autologous cell product gavo-cel (TC-210) is being studied in a Phase 1/2 trial for treatment refractory mesothelin-expressing solid tumors, ovarian cancer, NSCLC, and cholangiocarcinoma. In addition, our emerging and dynamic oncology pipeline focuses on a series of next-generation enhancements, novel targets and an allogeneic platform which may further improve clinical outcomes and broaden patient access.  We are headquartered in Cambridge, Massachusetts with a clinical manufacturing facility in Rockville, MD. This role will be based in Cambridge, MA.

We are seeking an enthusiastic co-op to join our Downstream Process Development team.  This will be a unique learning opportunity to get experience with developing a downstream purification platform process for virus-based products coming through our research candidate pipeline.  You will report to a Senior Scientist on the Vector process development – Downstream processing team and will be hands on in refining several chemical engineering unit operations, and performing analytical assays.  Additionally, you will have the opportunity to work alongside a talented group of upstream and downstream process development scientists, analytical experts, and T cell biologists.

What you will learn:

• Execution of laboratory tasks under supervision of an experienced Sr. Scientist, such as:
  • Performing chemical engineering unit operations, such as harvest clarification, sterilizing-grade filtration, liqiuid chromatography, ultrafiltration/diafiltration.
  • Performing analytical assays such as flow cytometry, cytokine-based assays (e.g. ELISA), protein and DNA quantitation.
• Analysis and interpretation of experimental results, under supervision.
• Appropriately documenting experimental results, including raw data, analyzed data, and summarization.
• Sharing results with the Vector process development group through participation in lab meetings.

Who you are:

• Enrolled in a biology-related B.S./M.S. program, or engineering discipline with basic knowledge of biology.
• Previous research experience, such as an industry co-op/intern experience, preferred but not required.
• Experience in preparing buffers, performing titrations, mammalian cell culture, flow cytometry, MSD or other cytokine-based assays (e.g. ELISA) are a bonus.
• Team-oriented personality.
• Interested in working in a fast-paced and exciting environment.

At TCR² Therapeutics Inc, our inclusive and diverse team is passionate about curing cancer. We are a clinical-stage cell therapy company pioneering the development of novel T cell therapies by utilizing our TRuC platform. Our lead autologous cell product gavo-cel (TC-210) is being studied in a Phase 1/2 trial for treatment refractory mesothelin-expressing solid tumors. In addition, our emerging and dynamic oncology pipeline focuses on a series of next-generation enhancements, novel targets and an allogeneic platform which may further improve clinical outcomes and broaden patient access. We are headquartered in Cambridge, Massachusetts with a clinical manufacturing facility in Rockville, MD

We are growing and looking for Process Development Co-Ops. You will have the opportunity to either work on with the T Cell Production team on the development of a robust and scalable manufacturing process.

This role is a unique opportunity to learn and advance your career development actively working with an experienced team and highly collaborative environment. We are experiencing high-growth and this is an opportunity for conversion for students who are nearing graduation. 

 What you will learn:

• Learn and utilize new skills to help develop T Cell Production processes including T cell isolation, enrichment, activation, transduction, expansion, and cryopreservation
• Learn the execution of key projects through both independent execution and collaboration with other team members
• Learn to generate data through well-defined and executed design of experiment studies, while organizing and prioritizing work to meet timelines

 Who you are:

• You are in a BS or MS program in biotechnology, immunology, cell biology or related discipline 
• You must have hands on technical experience with cell culture handling. Experience with in-vitro cell-based assays involving flow cytometry is preferred and is an opportunity to learn
• Outstanding critical thinking and organizational skills, leadership, and attention to detail
• Team-based candidate interested in an exciting start-up environment!

At TCR² Therapeutics Inc, our inclusive and diverse team is passionate about curing cancer. We are a clinical-stage immunotherapy company pioneering the development of novel T cell therapies. Our two lead cell product candidates are being studied in Phase 1/2 trials: TC-210 for solid tumors and TC-110 for hematological malignancies. Our research efforts focus on broadening our pipeline with a series of next-generation enhancements that may further improve clinical outcomes. We are headquartered in Cambridge, Massachusetts and have a clinical manufacturing facility in Stevenage, UK. This role is located in Cambridge, Massachusetts. 

We are looking for a Senior Research Associate to perform testing of cellular drug products using complex bioassays and participate in T Cell product characterization studies. You will report to our Associate Director, Analytical Development and work closely with the Regulatory and T Cell Process Development teams. 

Your primary responsibilities will include testing of manufactured T Cells, and characterization of engineered T Cells for product and attribute understanding. Additional activities could include evaluation of new technologies, improving existing assays, and authorship of technical documents. The position represents an excellent opportunity for career development, working closely with experienced scientists in a fast-paced and highly collaborative environment. 

Responsibilities: 

• Execute a variety of analytical methods, including cell based assays, ELISAs, and flow cytometry. 

• Analyze data, document results, and write corresponding technical reports for product characterization studies. 

• Work closely and effectively with cross-functional teams, including Process Development, Regulatory, and Quality. 

• This is a hands-on position requiring execution of laboratory experiments. 

Requirements: 

• M.S. in biochemistry, chemical engineering, or related discipline with 2+ years relevant industry experience, or B.S. with 3+ years relevant industry experience.  

• Industry experience is required for this position. 

• Experience with analytical assays required, with emphasis on cell and plate-based assays. 

• Experience with flow cytometry, mammalian cell culture, and/or primary human cells a plus. 

• Strong technical writing skills with industry experience writing technical reports is required. 

• Outstanding critical thinking and organizational skills, leadership, and attention to detail. 

• Team-based candidate interested in a fast-paced, exciting, start-up environment! 

At TCR² Therapeutics Inc, our inclusive and diverse team is passionate about curing cancer. We are a clinical-stage cell therapy company pioneering the development of novel T cell therapies by utilizing our TRuC platform. Our lead autologous cell product gavo-cel (TC-210) is being studied in a Phase 1/2 trial for treatment refractory mesothelin-expressing solid tumors. In addition, our emerging and dynamic oncology pipeline focuses on a series of next-generation enhancements, novel targets and an allogeneic platform which may further improve clinical outcomes and broaden patient access.

We are headquartered in Cambridge, Massachusetts with a clinical manufacturing facility in Rockville, MD 

We are looking for a Principal Scientist to join the T Cell Process Development group to work on the late-stage development, characterization, and commercialization of novel autologous and allogeneic TRuC-T cell programs as well as support regulatory filings. Under minimal supervision, you will be expected to design, manage, and perform experiments, organizing, analyzing, and carefully documenting results, as well as communicate findings. This is an excellent opportunity for career development, working closely with the Viral Vector and Analytical Development groups leading a team of scientists and associates in a fast-paced and highly collaborative environment.

Responsibilities:

• Individually contributing and leading a team of 2-3 Scientists/ associates to establish small scale model(s) for T-cell Manufacturing.
• Lead the design and execution of process development studies to develop a thorough understanding of operating and performance parameters (Design space) for T cell manufacturing processes.
• Performs gap analysis and risk assessments to identify problems and deficiencies, as well as provide recommendations for studies and solutions to manufacturing process.
• Develops and leads strong collaborative relationships with internal and external groups. 
• Lead tech transfer activities for T-cell operations to manufacturing sites.
• Support the development of standard operating procedures, FMEA, batch records, and analytical sampling plans.
• Serve as Subject Matter Expert (SME) for operations for T-cell Manufacturing.

Requirements:

• M.S. or Ph.D. in Engineering, science or biology science.
• M.S. with 7+ years or Ph.D. with 4+ years of relevant industry experience. 
• Experience with process characterization, scale-up and/or technology transfer required.
• Experience using Design of Experiment (DOE) and statistical analysis using tools such as JMP.
• Familiarity with commercialization of cell-based therapeutics preferred.
• Experience with functionally closed systems preferred.
• Outstanding critical thinking and organizational skills, leadership, and attention to detail.
• Comfortable in a fast-paced small company environment with minimal direction and able to adjust workload based upon changing priorities.

At TCR² Therapeutics Inc, our inclusive and diverse team is passionate about curing cancer. We are a clinical-stage cell therapy company pioneering the development of novel T cell therapies by utilizing our TRuC platform. Our lead autologous cell product gavo-cel (TC-210) is being studied in a Phase 1/2 trial for treatment refractory mesothelin-expressing solid tumors. In addition, our emerging and dynamic oncology pipeline focuses on a series of next-generation enhancements, novel targets and an allogeneic platform which may further improve clinical outcomes and broaden patient access.

We are headquartered in Cambridge, Massachusetts with a clinical manufacturing facility in Rockville, MD 

We are looking for a Scientist to join the T Cell Process Development group to work on the late-stage development, characterization, and commercialization of novel autologous and allogeneic TRuC-T cell programs as well as support regulatory filings. You will support / lead experimental design, execution, analysis, and reporting of experiments related to design space and process characterization activities for T-cell manufacturing. This is an excellent opportunity for career development, working closely with the Viral Vector and Analytical Development groups comprised of experienced scientists and associates in a fast-paced and highly collaborative environment.

Responsibilities:

• Support development of small-scale model(s) for T cell Manufacturing.
• Support / lead the design and execution of process development studies to develop a thorough understanding of operating and performance parameters (Design space) for T cell manufacturing processes.
• Perform in-vitro cellular assays involving flow cytometric, molecular and functional characterization of genetically engineered primary T cells.
• Perform gap analysis and risk assessments to identify problems and deficiencies, as well as provide recommendations for studies and solutions to manufacturing process. 
• Lead tech transfer activities for T-cell operations to manufacturing sites.
• Support the development of standard operating procedures, FMEA, batch records, and analytical sampling plans.
• Serve as Subject Matter Expert (SME) for operations for T-cell Manufacturing.
• Support regulatory agency filings.

Requirements:

• B.S., M.S. or Ph.D. in Engineering, science or biology science.
• B.S. with 6+ years or M.S. with 3+ years or Ph.D. with 1+ years of relevant industry experience. 
• Experience using Design of Experiment (DOE) and statistical analysis using tools such as JMP.
• Experience with process characterization, scale-up and/or technology transfer preferred.
• Familiarity with commercialization of cell-based therapeutics preferred.
• Experience with functionally closed systems preferred.
• Outstanding critical thinking and organizational skills, leadership, and attention to detail.
• Comfortable in a fast-paced small company environment with minimal direction and able to adjust workload based upon changing priorities.

At TCR² Therapeutics Inc, our inclusive and diverse team is passionate about curing cancer. We are a clinical-stage cell therapy company pioneering the development of novel T cell therapies by utilizing our TRuC platform. Our lead autologous cell product gavo-cel (TC-210) is being studied in a Phase 1/2 trial for treatment refractory mesothelin-expressing solid tumors. In addition, our emerging and dynamic oncology pipeline focuses on a series of next-generation enhancements, novel targets and an allogeneic platform which may further improve clinical outcomes and broaden patient access.

We are headquartered in Cambridge, Massachusetts with a clinical manufacturing facility in Rockville, MD. This role will be based in Cambridge, MA.

We are looking for an enthusiastic, motivated Senior Manager, Clinical Quality to provide oversight to the GCP Audits and qualification activities of our clinical studies. You will report to our Director, Research & Clinical Quality and work closely with internal and external cross-functional groups to ensure compliance with regulatory requirements and to support clinical initiatives. We’re looking for someone who can build and execute the GCP audit/qualification process for external suppliers/CROs/investigator sites. If you thrive in a highly collaborative, fast-paced environment and are looking for a role where you’re given ownership and accountability to get results and make an impact, come grow your career with us.

Responsibilities:

• Develop and execute a risk based clinical  quality audit/investigator site/vendor qualification process, and integrate this process into the Quality Management System (QMS).
• Audit internal clinical processes, clinical investigator sites, and vendors to assess compliance with applicable  regulations and guidelines
• Analyze and trend audit observations, gaps, and systematic issues to support continous improvement within preclinical/clinical development programs, vendors, and interfacing functional groups.
• Manage the audit processes to ensure project timeline and quality of deliverable are met
• Participate with the development and implementation of procedures, processes, etc.for the GCP audit program
• Manage CRO to vendor quality collaboration through the establishment of quality agreements facilitations of Quality to Quality meetings
• Maintain current and accurate records of all relevant communications, reports, actions and monitoring of audit/qualification activities
• Generate and report quality metrics of audit activities at management review
• Contribute to GCP inspection readiness team, including inspection readiness planning, facilitating completion of inspection readiness, hosting and management
• Serve as subject matter expert for GCP regulations and requirements
• Demonstrate strong proficiency in the application of the CAPA system to ensure actions, verification and closure of effectiveness of solutions applied to root cause issues originating from CROs audits or other sources.
• Travel up to 20% of the time.

Requirements:

• Bachelor’s degree in the biological sciences or related field.
• 8+ years of clinical monitoring or quality assurance experience in the pharmaceutical/biotechnology field
• Auditor certification highly preferred
• Experience with auditing/qualification of suppliers/CROs
• Understanding/working knowledge with ICH and GCP guidelines
• Process-oriented, with the ability to demonstrate good judgment and decision-making
• Strong techinical writing skills, specifically with effective report, investigation documents experience
• Excellent communication, collaboration, partnering, and influencing skills required

At TCR² Therapeutics Inc, our inclusive and diverse team is passionate about curing cancer. We are a clinical-stage cell therapy company pioneering the development of novel T cell therapies by utilizing our TRuC platform. Our lead autologous cell product gavo-cel (TC-210) is being studied in a Phase 1/2 trial for treatment refractory mesothelin-expressing solid tumors. In addition, our emerging and dynamic oncology pipeline focuses on a series of next-generation enhancements, novel targets and an allogeneic platform which may further improve clinical outcomes and broaden patient access.

We are headquartered in Cambridge, Massachusetts with a clinical manufacturing facility in Rockville, MD. This role will be based in Cambridge, MA.

We are looking for an enthusiastic, motivated Senior Manager, Clinical Quality to provide oversight to the GCP systems and compliance of our clinical studies. You will report to our Director, Research & Clinical Quality and work closely with groups throughout the organization to ensure compliance with regulatory requirements and to support clinical initiatives. The individual in this role will be responsible for providing Quality support to the external and internal functions to ensure robust processes and systems are implemented to support the clinical programs. If you thrive in a highly collaborative, fast-paced environment and are looking for a role where you’re given ownership and accountability to get results and make an impact, come grow your career with us.

Responsibilities:

• Serve as subject matter expert for GCP regulations and requirements
• Provide guidance to CRO to ensure study issues are addressed and resolved
• Manage the quality aspects of all cross functional areas involved in the clinical studies
• Liaise with clinical functions and external parties including CROs, vendors, and investigator sites to promote a high level of quality and consistency across and within programs
• Support Clinical trial managers/Directors with clinical trial activities
• Identify noncompliance trends and systematic risks for assigned areas of responsibility
• Participate with the development and implementation of procedures, processes, etc.for the GCP program
• Review and approve essential monitoring documents and plans
• Review outcomes/actions related to protocol deviations; identifying trends across investigator sites or the study
• Document review and monitoring risks and decisions at the study level and implementation of mitigation strategies
• Participate in clinical document reviews including regulatory submissions, study report, protocols, and SOPs
• Generate and report quality metrics of compliance activities at management review
• Work collaboratively with Data managers and internal functional teams to ensure that data management functions are performed in compliance with regulations and study protocol and procedures
• Support regulatory authority inspections as required
• Demonstrate strong proficiency in the application of the CAPA system to ensure actions, verification and closure of effectiveness of solutions applied to root cause issues originating from CROs audits or other sources.

Requirements:

• Bachelor’s degree in the biological sciences or related field.
• 8+ years of clinical monitoring or quality assurance experience in the pharmaceutical/biotechnology field
• Understanding/working knowledge with ICH and GCP guidelines
• Process-oriented, with the ability to demonstrate good judgment and decision-making
• Exceptional organizational skills and ability to deal with competing priorities
• Experience with Protocol, ICF, CRF, CSR development and review
• Strong technical writing skills, specifically with effective report, investigation documents experience
• Excellent communication, collaboration, partnering, and influencing skills required

At TCR² Therapeutics Inc, our inclusive and diverse team is passionate about curing cancer. We are a clinical-stage cell therapy company pioneering the development of novel T cell therapies by utilizing our TRuC platform. Our lead autologous cell product gavo-cel (TC-210) is being studied in a Phase 1/2 trial for treatment refractory mesothelin-expressing solid tumors. In addition, our emerging and dynamic oncology pipeline focuses on a series of next-generation enhancements, novel targets and an allogeneic platform which may further improve clinical outcomes and broaden patient access.

We are growing our quality organization and looking for a Quality Manager, Document Control & Training to joing the TCR2 Quality Systems and Engineering team. In this role you will be an integral part of the organization by promoting the meaning and purpose of document and training management. You will be responsible for ensuring compliance with document management, record retention, and training management requirements. Additionally, you will assist with the development of policies and procedures for additional quality systems enterprise elements. 

Responsabilities:

• Serve as the business system owner for the EQMS to control, issue, retain, and archive controlled documents and records
• Ensure that the Document Management Team maintains quality and timely processing of documentation
• Provide technical guidance and help team members in the use of the document management tools
• Provide Document Management and EDMS guidance and training
• Support the implementation and continuous improvement of quality systems processes
• Implement and coordinate the training program to oversee creation of training plans, qualification programs, completion of required GxP and departmental training, evaluation of training processes, and identification and coordination of supplemental training
• Work with stakeholders to develop training materials for existing employees ensuring all aspects of job responsibilities and expectations are met to improve efficiency, effectiveness and compliance and address gaps appropriately
• Provide guidance and information to leadership on recommended training programs, curricula and training material development, and learning assignments
• Generate and evaluate Quality metrics related to document and training management
• Evaluate and implement work process improvements
• Author / write and review SOPs / documentation
• Train New Hires, as applicable
• Other duties, as assigned

Requirements:

• Bachelor’s degree and 5+ years of relevant work experience in a GMP regulated industry, or 10 years of relevant QMS experience 
• Prior supervisory or leadership is preferred 
• Experience with Veeva is highly desired, experience with at least one EDMS and LMS is required
• Experience with data organization and analysis in the creation of reports, trackers, and dashboards
• Able to independently anticipate changing priorities, unscheduled work tasks and effectively flow down changes to work team
• Must be comfortable influencing and driving change
• Understand and interpret regulations and standards (i.e, including 21 CFR part 11, 210/211, 606, ISO 9001, and EU industry standards)
• Proficient with Microsoft Suite (Word, Excel, PowerPoint)
• Excellent verbal and written communication skills
• Ability to work independently with minimal oversight
• Must be authorized to work in the U.S.

At TCR² Therapeutics Inc, our inclusive and diverse team is passionate about curing cancer. We are a clinical-stage cell therapy company pioneering the development of novel T cell therapies by utilizing our TRuC platform. Our lead autologous cell product gavo-cel (TC-210) is being studied in a Phase 1/2 trial for treatment refractory mesothelin-expressing solid tumors. In addition, our emerging and dynamic oncology pipeline focuses on a series of next-generation enhancements, novel targets and an allogeneic platform which may further improve clinical outcomes and broaden patient access.

We are headquartered in Cambridge, Massachusetts with a clinical manufacturing facility in Rockville, MD. This role will be based in Cambridge, MA.

We are growing and looking for a Sr. Quality Compliance Associate, Supplier Quality & Audits. As a member of the TCR2 Quality Systems and Engineering team, you will directly support risk management of product to ensure patient safety overseeing the supplier quality and audit program. Additionally, you will support regulatory inspections, material release and qualification, the establishment of an internal audit program, and improvements to the existing supplier quality and audits program. If you want to join a growing Quality organization and have a meaningful impact on patients lives, we want to hear from you!

Responsabilities:

• Develop, lead, and support an Inspection Readiness program for cGMP departments, including participating and leading internal audits, participating in regulatory audits, and assessing regulatory guidance and updates
• Create, maintain, and distribute Compliance Quality Metrics to upper management on a routine basis, includes identifying, reporting, and escalating relevant Quality issues
• Plan and conduct (remote and onsite) supplier audits on a regular basis to ensure suppliers and their supplies remain in compliance with company requirements and industry regulations and standards
• Communicate with suppliers regularly to address any concerns, improve performance, and foster an environment that facilitates continual improvement in working relationships
• Perform investigation and analysis of supplier complaints and notification of changes
• Perform periodic facility walkthroughs to identify compliance risks before audits or inspections
• Support review and disposition of incoming materials, and material qualification as required
• Drive Compliance Lean Initiatives
• Author / write and review SOPs / documentation
• Train New Hires, as applicable
• Other duties, as assigned

Requirements:

• Bachelor’s degree in a science / technical field such as Pharmacy, Biology, Chemistry or Engineering
• 5+ years of experience with GMP-regulated industries; Pharmaceutical Quality Assurance, Quality Systems, and Supplier Management background. Or 3+ years of experience with additional education in a related field may be considered
• Experience as a Lead Auditor with certification is highly desired
• Previous Quality Compliance (performing internal and supplier audits) experience is required, as is prior knowledge of US and International cGMP regulations
• Understand and interpret regulations and standards (i.e, including 21 CFR part 11, 58, 210/211, 606, 820, ISO 9001, 13485, 17025, 19011, and EU industry standards)
• Proficient with Microsoft Suite (Word, Excel. PowerPoint), experience with Visio is a plus.
• Experience working with Veeva is preferred
• Excellent verbal and written communication skills
• Must be authorized to work in the U.S.
• Travel up to 25%

At TCR² Therapeutics Inc, our inclusive and diverse team is passionate about curing cancer. We are a clinical-stage immunotherapy company pioneering the development of novel T cell therapies. Our two lead cell product candidates are being studied in Phase 1/2 trials: TC-210 for solid tumors and TC-510 for hematological malignancies. Our research efforts focus on broadening our pipeline with a series of next-generation enhancements that may further improve clinical outcomes.

We are headquartered in Cambridge, Massachusetts and are building an internal manufacturing facility in Rockville, MD. This remote-capable role is based in Cambridge, Massachusetts.

We are looking for a hands-on Quality Control (QC) Manager to work directly with our critical external testing laboratory partners and drive consistent, flawless execution of analytical testing associated with our autologous cell therapies.  You will report to the Associate Director of External Quality Control and collaborate closely with our Analytical Development, Quality Assurance, Manufacturing, and Supply Chain teams on clinical pipeline programs to help prepare the company for Phase 2-3/Pivotal trials and beyond.  You will have the opportunity to become a subject matter expert with leading edge technology while gaining valuable operational and partnership management skills.  This position is also a great opportunity to have a direct impact on patients. If you thrive in a highly collaborative, fast-paced environment and are looking for a role where you’re given ownership and accountability to get results and make an impact, we want to hear from you.

Responsibilities:

• Take an active role in the oversight and continuous improvement of partner company QC operations, particularly analytical testing.
• Review and evaluate test data, COA/COCs, and other test information to support the release of drug product for clinical use
• Drive successful method transfer, validation, optimization, and harmonization across our entire network
• Lead investigation and resolution of issues causing out-of-specification or out-of-trend results
• Monitor, analyze, trend, and report (including Quality Management Review) test results.
• Participate in and/or lead improvements to analytical testing strategy.
• Participate in audits of laboratories as a subject matter expert
• Support development and maintenance of quality agreements.
• Develop, oversee, and conduct training programs as directed.

Requirements:

• Bachelors or Masters degree in Biochemistry, Micro/Molecular Biology, or related field.
• Minimum of 5 years experience in QC or Analytical Development role in a biotech or biologics operation with progressively increasing responsibility in a lead capacity.
• Proven experience in various analytical techniques commonly used for cell and gene therapy testing, including flow cytometry, ELISAs, qPCR/ddPCR, and cell-based assays. 
• Experience with transfer, qualification, and validation of methods
• Strong technical writing skills, specifically with effective protocol, report, and investigation document experience
• Excellent communication, collaboration, partnering, and influencing skills required
• Possess a flexible yet pragmatic approach to problem solving, be an adept negotiator and apply risk-based decisions
• At home in a results-driven, highly accountable collaborative environment where you can make a clear impact.

TCR² has embarked on establishing a cGMP manufacturing operations to provide manufacturing capacity for Phase 1 and Phase 2 operations, and beyond, for the TRuC^TM T cell platform. The Quality Assurance Sr. Associate will support quality operations under under the Quality Management System environment including product and batch record review, tracking training and deviations, change management, equipment validaton,  and assisting with documentation control activities.  In addition, The QA Sr. Associate will support Research Operating Procedure development, document control and and tracking training for the non-GMP departments.

Responsibilities:

• Maintain quality supporting documentation to facilitate GMP production including tech transfers and equipment qualification/validation at CMOs.
• Perform review of manufacturing records and perform batch release for clinical lots.
• Manage Quality Change Control projects.
• Review Change Control records impacting T cell therapy product and provide QA support for other changes.
• Provide investigational support for deviations for the manufacture, testing, and shipping of raw materials or drug product.
• Write and revise quality SOPs and associated documentation to support GMP production.
• Support the quality vendor approval for suppliers, contractors and service providers, assit with external audits.
• Conduct training for GMP and GDP processing.
• Perform deviation review and implementation of CAPA to improve product quality.
• Liaison with UK Quality department on quality related issues and provide support as needed.

Qualifications and Experience:

• Bachelor’s degree in the biological sciences or related field.
• Minimum of 5 years GMP experience in a biotech, or biologics operation, or equivalent education/work experience.
• Knowledge of Quality Management System elements and experience in maintaining and impoving systems supporting the QMS.
• Prior experience in a quality function (quality assurance or quality control), preferably in a commercial environment.
• Working knowledge and ability to apply GMPs in conformance with FDA, MHRA, EU and ICH standards, preferably gained from working in a manufacturing or QC environment.
• Good interpersonal, verbal and written communication skills.
• Comfortable in a fast-paced small company environment with minimal direction.
• External auditing experience preferred.

At TCR² Therapeutics Inc, our inclusive and diverse team is passionate about curing cancer. We are a clinical-stage immunotherapy company pioneering the development of novel T cell therapies. Our two lead cell product candidates are being studied in Phase 1/2 trials: TC-210 for solid tumors and TC-510 for hematological malignancies. Our research efforts focus on broadening our pipeline with a series of next-generation enhancements that may further improve clinical outcomes.

We are headquartered in Cambridge, Massachusetts and are building an internal manufacturing facility in Rockville, MD. This role is based in Cambridge, Massachusetts.

We are looking for a Quality Control Associate to work with our critical external testing laboratory partners and drive consistent, flawless execution of analytical testing associated with our autologous cell therapies. You will report to the Manager of External Quality Control and collaborate closely with our Quality Assurance, Manufacturing, and Supply Chain teams on clinical pipeline programs to help prepare the company for Phase 2-3/Pivotal trials and beyond. You will have the opportunity to work on leading edge technology while gaining valuable operational and partnership management skills. This position is also a great opportunity to have a direct impact on patients. If you thrive in a highly collaborative, fast-paced environment, are looking for a role where you’re given ownership and accountability to get results and make an impact, we want to hear from you.

Responsibilities:

• Review and evaluate test data, COA/COCs, and other test information to support the release of drug product for clinical use
• Monitor, analyze, trend, review and report test results.
• Support investigation and resolution of issues causing out-of-specification or out-of-trend results
• Participate in improvements to analytical testing strategy.
• Take an active role in the oversight and continuous improvement of partner company QC operations, particularly analytical testing

Requirements:

• Bachelors or Masters degree in Biochemistry, Micro/Molecular Biology, or related field.
• Minimum of 2 years experience in QC or Analytical Development role in a biotech or biologics operation
• Proficiency in GDP, and experience in analytical method data review and verification.
• Experience in various analytical techniques commonly used for cell and gene therapy testing, including flow cytometry, ELISAs, qPCR/ddPCR, and cell-based assays. 
• Experience with transfer, qualification, and validation of methods preferred.
• Technical writing skills, specifically with effective protocol.
• Excellent communication and collaboration skills required.
• Possess a flexible yet pragmatic approach to problem solving.
• At home in a results-driven, highly accountable collaborative environment where you can make a clear impact.

Clinical Quality Associate

At TCR² Therapeutics Inc, our inclusive and diverse team is passionate about curing cancer. We are a clinical-stage cell therapy company pioneering the development of novel T cell therapies by utilizing our TRuC platform. Our lead autologous cell product gavo-cel (TC-210) is being studied in a Phase 1/2 trial for treatment refractory mesothelin-expressing solid tumors. In addition, our emerging and dynamic oncology pipeline focuses on a series of next-generation enhancements, novel targets and an allogeneic platform which may further improve clinical outcomes and broaden patient access.

We are headquartered in Cambridge, Massachusetts with a clinical manufacturing facility in Rockville, MD. This role will be based in Cambridge, MA.

We are looking for an enthusiastic Clinical Quality Associate to support the GCP activities of our clinical studies. You will report to our Manager, Clinical Quality and work closely with groups throughout the organization to ensure compliance with regulatory requirements and to support clinical initiatives. We’re looking for someone who can support the GCP audit/qualification process for external suppliers/CROs/investigator sites. If you thrive in a highly collaborative, fast-paced environment and are looking for a role where you’re given ownership and accountability to get results and make an impact.

Responsibilities:

• Coordinate and support audits of the TMF, clinical investigation sites, CROs, vendors, and internal GCP activities
• Assist with the ongoing assessment of clinical investigator site, CRO, and vendor performance during the trials
• Maintain current and accurate records of all relevant communications, reports, actions and monitoring of audit/qualification activities
• Collaborate in the development of departmental SOPs, Work Instructions, Policies, and forms.
• Assisting with the development, monitoring and reporting of Quality metrics
• Assist with the review of essential monitoring documents and plans
• Assist in the investigation of deviations and CAPAs
• Provide GCP quality support to Clinical Operations study teams
• Support regulatory authority inspections as needed
• Travel up to 20% of the time.

Requirements:

• Bachelor’s degree in the biological sciences or related field.
• 3+ years of clinical monitoring or quality assurance experience in the pharmaceutical/biotechnology field
• Experience with auditing/qualification of suppliers/CROs
• Understanding/working knowledge with ICH and GCP guidelines
• Process-oriented, with the ability to demonstrate good judgment and decision-making
• Strong techinical writing skills, specifically with effective report, investigation documents experience
• Excellent communication, collaboration, partnering, and influencing skills required

At TCR² Therapeutics Inc, our inclusive and diverse team is passionate about curing cancer. We are a clinical-stage cell therapy company pioneering the development of novel T cell therapies by utilizing our TRuC platform. Our lead autologous cell product gavo-cel (TC-210) is being studied in a Phase 1/2 trial for treatment refractory mesothelin-expressing solid tumors. In addition, our emerging and dynamic oncology pipeline focuses on a series of next-generation enhancements, novel targets and an allogeneic platform which may further improve clinical outcomes and broaden patient access.

We are headquartered in Cambridge, Massachusetts with a clinical manufacturing facility in Rockville, MD. This role will be based in Cambridge, MA.

We are seeking a talented In Vivo Scientist with a strong background in cancer immunotherapy to support the advancement of TCR2’s pipeline of targeted TRuC T cell therapies. Reporting to the Sr. Director of Pharmacology you will have extensive hands-on experience with mouse tumor models for immuno-oncology and will apply these skills to develop models tailored to address target and/or indication-specific biology. You are a highly motivated, interactive and creative scientist who will oversee the design and execution of xenograft and syngeneic mouse tumor model studies that will guide lead candidate selection and demonstrate preclinical proof-of-concept for enhancement strategies.  

Responsibilities:

• Devise and execute tumor model strategies for TRuC T cell programs based on a deep scientific understanding of target & indication biology
• Design and engineer tumor models relevant for assessing the efficacy of TRuC T cells bearing a variety of enhancement constructs designed to improve T cell function and overcome tumor immune evasion
• Oversee the execution of in vivo pharmacology studies aimed at identifying lead candidates for novel TRuC T cell therapies and selecting optimal enhancements or combinations of enhancements
• Collaborate across multiple cross-functional program teams, providing leadership on tumor model selection and development 
• Analyze, interpret, and present research findings to internal and external audiences

Requirements:

• Ph.D.* in biology-related discipline with 1-2 years of post-Ph.D. research experience, in the in vivo evaluation of cancer immunotherapies
• Highly proficient in the technical performance of xenogeneic and syngeneic mouse tumor model studies with extensive experience in model development and validation
• Proven ability to engineer tumor cell lines to express multiple proteins of interest
• Strong understanding of tumor immunology and tumor cell biology
• Prior experience with T cell therapies is highly desirable
• Excellent oral and written communication skills
• Keen attention to detail with excellent organizational and record-keeping skills

*Candidates without a Ph.D. may be considered if they have commensurate experience

At TCR² Therapeutics Inc, our inclusive and diverse team is passionate about curing cancer. We are a clinical-stage immunotherapy company pioneering the development of novel T Cell Receptor Fusion Construct (TRuC) T cell therapies. Our lead autologous cell product gavo-cel (TC-210) is being studied in a Phase 1/2 trial for treatment refractory mesothelin-expressing solid tumors. Our research efforts focus on broadening our pipeline with a series of next-generation enhancements that may further improve clinical outcomes, and developing allogeneic “off-the-shelf” TRuC T cells to further broaden patient access. We are headquartered in Cambridge, Massachusetts with a clinical manufacturing facility in Rockville, MD.

We are looking for an enthusiastic Co-Op to join our dynamic T Cell Engineering team. This will be a unique learning opportunity to get experience with the development of allogeneic T cell therapies. You will be part of the team getting hands on experience screening the candidates for our pipeline programs and contribute to the nomination of clinical lead. You will be trained and work together with a group of talented and experienced T cell biologists on various type of assays characterizing the T cell products and have fun along the way!

What you will learn:

• Laboratory skills under supervision of an experienced Scientist, including but not limited to:
  • Tumor cell line culture
  • TRuC T cell generation with primary T cells
  • Phenotyping of TRuC T cells by flow cytometry
  • Functional assays to evaluate TRuC T cells anti-tumor efficacy in vitro
  • Functional assays to evaluate TRuC T cells susceptibility to host rejection in vitro
• Analyze and interpretate experiment results under supervision
• Document experiment results, including raw data, analyzed data, and summary accordingly

Who you are:

• B.S./M.S. in a scientific or engineering discipline, with previous research experience preferred, ideally with industry Co-Op/Intern experience
• Experience and/or interest in learning mammalian (T or NK) cell culture, flow cytometry, ELISA, or MSD
• Outstanding critical thinking and organizational skills
• Team-oriented candidate interested in a fast-paced, exciting, start-up environment!

At TCR² Therapeutics Inc, our inclusive and diverse team is passionate about curing cancer. We are a clinical-stage cell therapy company pioneering the development of novel T cell therapies by utilizing our TRuC platform. Our lead autologous cell product gavo-cel (TC-210) is being studied in a Phase 1/2 trial for treatment refractory mesothelin-expressing solid tumors, ovarian cancer, NSCLC, and cholangiocarcinoma. In addition, our emerging and dynamic oncology pipeline focuses on a series of next-generation enhancements, novel targets and an allogeneic platform which may further improve clinical outcomes and broaden patient access.  We are headquartered in Cambridge, Massachusetts with a clinical manufacturing facility in Rockville, MD. This role will be based in Cambridge, MA.

We are seeking an enthusiastic co-op to join our Early Discovery team.  This will be a unique learning opportunity to get experience with the pre-clinical research necessary for our T cell products.  You will report to a Senior Scientist on the Early Discovery team and will be hands on in screening and testing enhancement candidates for our TRuC-T cell pipeline.  Additionally, you will have the opportunity to work alongside a talented group of immunologists and T cell biologists.

What you will learn:

• Execution of laboratory tasks under supervision of an experienced Sr. Scientist, such as:
  • Generating TRuC-T cells from primary T cells.
  • Characterizing TRuC-T cells via flow cytometry.
  • Evaluating TRuC-T cells using in vitro functional assays.
  • Maintaining tumor cell line cultures.
• Analysis and interpretation of experimental results, under supervision.
• Appropriately documenting experimental results, including raw data, analyzed data, and summarization.
• Sharing results with the Early Discovery group through participation in lab meeting.

Who you are:

• Enrolled in a biology-related B.S./M.S. program, or engineering discipline with basic knowledge of biology.
• Previous research experience, such as an industry co-op/intern experience, preferred but not required.
• Experience in performing mammalian cell culture, flow cytometry, MSD or other cytokine-based assays (e.g. ELISA) are a bonus.
• Team-oriented personality.
• Interested in working in a fast-paced and exciting environment.

At TCR² Therapeutics Inc, our inclusive and diverse team is passionate about curing cancer. We are a clinical-stage cell therapy company pioneering the development of novel T cell therapies by utilizing our TRuC platform. Our lead autologous cell product gavo-cel (TC-210) is being studied in a Phase 1/2 trial for treatment refractory mesothelin-expressing solid tumors. In addition, our emerging and dynamic oncology pipeline focuses on a series of next-generation enhancements, novel targets and an allogeneic platform which may further improve clinical outcomes and broaden patient access.

We are headquartered in Cambridge, Massachusetts and a  manufacturing facility in Rockville, MD which we can now call home for clinical & commercial manufacturing.

We are designing the state-of-the-art cell therapy facility in Rockville to utilize semi-automated and functionally closed systems which aim to provide cGMP manufacturing while optimizing the reliability of our cell therapy products and reducing manufacturing costs and vein-to-vein time. The flexible layout will allow production of gavo-cel and other emerging cell therapies in the TRuC-T cell pipeline.

The Rockville, Maryland site will support clinical and commercial production of gavo-cel with a capacity to treat several thousand cancer patients annually. This site is expected to accelerate TCR2’s commercial-scale manufacturing timelines with production anticipated in 2023. We will be hiring for positions throughout manufacturing, supply chain, and technical operations, as well as other functions.

If you are interested in joining us on this exciting journey please submit you information for future consideration and tailored job alerts. 

At TCR² Therapeutics Inc, our inclusive and diverse team is passionate about curing cancer. We are a clinical-stage cell therapy company pioneering the development of novel T cell therapies by utilizing our TRuC platform. Our lead autologous cell product gavo-cel (TC-210) is being studied in a Phase 1/2 trial for treatment refractory mesothelin-expressing solid tumors. In addition, our emerging and dynamic oncology pipeline focuses on a series of next-generation enhancements, novel targets and an allogeneic platform which may further improve clinical outcomes and broaden patient access. We are headquartered in Cambridge, Massachusetts with clinical manufacturing facilities in Stevenage, UK and Rockville, MD. 

Passion is at the heart of our research.

Our mission as a leader in the solid tumor field will always be to bring meaningful cellular therapies to cancer patients. With our positive interim gavo-cel data, our 2021 strategic goals are aimed at developing our emerging pipeline and further advancing our clinical programs – meaning we’re looking for someone passionate and driven like you to help us bring our therapies closer to reality as we rapidly grow. Being a part of the TCR2 team means more than just research and execution. Our efforts stretch beyond the lab with how we engage with the community with TCR2 Cares, where we support the cancer community and STEM education.

We will be hiring across all functions. Please submit your information to join our talent community for future consideration.