Principal Scientist, QC Analytical Development

TCR² Therapeutics Inc. is an immuno-oncology company developing novel cancer therapies that unleash the full signaling power of complete T cell receptors (TCR). TCR² has developed a unique proprietary TRuC™ platform which can reprogram the natural TCR complex to recognize specific antigens found on tumors where they elicit rapid killing of cancer cells. The company has demonstrated activity against both hematological and solid tumor targets in preclinical models and believes its TRuC™-reprogrammed T cells will serve as the engine for important therapies.  TCR² was founded by MPM Capital and has scientific operations in Cambridge, MA to leverage best-in-class technologies and nucleate top-tier academic laboratories around the world. 

The successful candidate will join the Process Development group to lead a team in the optimization of our manufacturing platform with a focus on analytic development of Quality Control assays for lentiviral vector and T cell therapy platform candidates. The position represents an excellent opportunity for career development, working closely with experienced scientists in a fast-paced and highly collaborative environment.

Primary Responsibilities:

  • Identify and execute on a strategy to develop and optimize quality control assays to support the clinical development of the TRuC™ platform.

  • Design, optimize, and/or qualify quality control assays that utilize platforms such as qPCR, flow cytometry, ELISA or other systems, as required.

  • Plan and supervise the development and execution of in vitro cellular assays involving flow cytometry, cytotoxicity and downstream molecular characterization of genetically engineered primary T cells as part of a potency assay development regime.

  • Apply new protocols and establish new methodologies and techniques by way of staying abreast of the latest methods and processes available to the industry.

  • Write protocols and operating procedures for technology transfer.

  • Work closely and effectively with CMOs for technology transfer and support.

  • Analyze and document scientific results for IND enabling studies throughout clinical development.

  • Lead research associates and scientists in interdepartmental programs.

  • Represent TCR² at scientific presentations and meetings.

  • Organize and prioritize work to meet timelines and ability to execute on multiple projects.

Secondary Responsibilities:

  • Coordinate in-house quality control assays throughput to facilitate internal development projects and the highest degree of quality for products used in R&D, in vivo and pre-clinical IND development studies.

  • Create, implement and manage a training and quality control worksheet data collection program to trend and track quality control functions.


  • Ph.D. in Immunology, Cell Biology or Bioengineering or related discipline with at least 6 years of relevant experience, preferably in industry.

  • Experience with lentiviral vector or CAR-T or TCR quality control programs preferred.

  • Expertise in flow cytometry and PCR.

  • Demonstrated experience in management of small teams of scientists and technicians.

  • Outstanding critical thinking and organizational skills, leadership, and attention to detail.

  • Ability to work in a collaborative, fast-paced environment.

  • Team-based candidate interested in a fast-paced, exciting, start-up environment!

Interested candidates should send their resume to