Principal Scientist, T Cell Manufacturing Process Development

The successful candidate will join the Process Development group to lead a team in the optimization of our T cell manufacturing platform with a focus on cell culture and cell processing strategies, evaluation of new technologies, product characterization, and support of the technology transfer to CMOs. The position represents an excellent opportunity for career development, working closely with experienced scientists in a fast-paced and highly collaborative environment.

Primary Responsibilities:

  • Identify and execute on a strategy to optimize the TRuC™ manufacturing platform

  • Plan and perform T cell manufacturing processes through design of experiment studies involving innovative and novel approaches to maximize production and reduce COGs

  • Design and initiate assays to characterize genetically engineered primary T cells to support product characterization

  • Plan and execute in-vitro cellular assays involving flow cytometry, cytotoxicity and downstream molecular characterization of genetically engineered primary T cells

  • Apply new protocols and establish new methodologies and techniques by way of staying abreast of latest methods and processes available to the industry

  • Write protocols and operating procedures for technology transfer

  • Work closely and effectively with CMOs for technology transfer and support

  • Analyze and document scientific results for IND enabling studies

  • Lead research associates and scientists in interdepartmental programs

  • Represent TCR² at scientific presentations and meetings

  • Organize and prioritize work to meet timelines and ability to execute on multiple projects

Secondary Responsibilities:

  • Perform T cell isolation, enrichment, activation, transduction, expansion and cryopreservation utilizing functional closed cell systems

  • Develop and optimize downstream assays for engineered T cells using qPCR, flow cytometry and cell based assays


  • Ph.D. in Immunology, Cell Biology or Bioengineering or related discipline with at least 6 years of relevant experience, preferably in industry

  • Experience with CAR-T or TCR process development and cGMP manufacturing

  • Understanding of the manufacture and use of chimeric antigen receptor (CAR) and genetically engineered T cells

  • Outstanding critical thinking and organizational skills, leadership, and attention to detail

  • Proven track record of scientific accomplishments demonstrated by publications in high-impact journals

  • Ability to work in a collaborative, fast-paced environment

Team-based candidate interested in a fast-paced, exciting, start-up environment!

Interested candidates should send their resume to