Principal Scientist, T Cell Process Development

TCR² Therapeutics Inc. is an immuno-oncology company developing novel cancer therapies that unleash the full signaling power of complete T cell receptors (TCR). TCR² has developed a unique proprietary TRuC™ platform which can reprogram the natural TCR complex to recognize specific antigens found on tumors where they elicit rapid killing of cancer cells. The company has demonstrated activity against both hematological and solid tumor targets in preclinical models and believes its TRuC™-reprogrammed T cells will serve as the engine for important therapies.  TCR² was founded by MPM Capital and has scientific operations in Cambridge, MA to leverage best-in-class technologies and nucleate top-tier academic laboratories around the world.

The successful candidate will join the Process Development group to lead a team in the optimization of our T cell manufacturing platform with a focus on cell culture and cell processing strategies, evaluation of new technologies, product characterization, and support of the technology transfer to CMOs. The position represents an excellent opportunity for career development, working closely with experienced scientists in a fast-paced and highly collaborative environment.

Primary Responsibilities:

  • Identify and execute on a strategy to optimize the TRuC™ manufacturing platform.

  • Plan and perform T cell manufacturing processes through design of experiment studies involving innovative and novel approaches to maximize production and reduce COG

  • Design and initiate assays to characterize genetically engineered primary T cells to support product characterization.

  • Plan and execute in-vitro cellular assays involving flow cytometry, cytotoxicity and downstream molecular characterization of genetically engineered primary T cells.

  • Write protocols and operating procedures for technology transfer.

  • Work closely and effectively with CMOs for technology transfer and support.

  • Analyze and document scientific results for IND enabling studies.

  • Lead research associates and scientists in interdepartmental programs.

  • Represent TCR² at scientific presentations and meetings.

  • Organize and prioritize work to meet timelines and ability to execute on multiple projects.

Secondary Responsibilities:

  • Perform T cell isolation, enrichment, activation, transduction, expansion and cryopreservation utilizing functional closed cell systems.

  • Develop and optimize downstream assays for engineered T cells using qPCR, flow cytometry and cell based assays.

Requirements:

  • Ph.D. in Immunology, Cell Biology or Bioengineering or related discipline with at least 6 years of relevant experience, preferably in industry.

  • Experience with CAR T or TCR process development and cGMP manufacturing,

  • Understanding of the development and manufacture of chimeric antigen receptor (CAR) or genetically engineered T-cells.

  • Outstanding critical thinking and organizational skills, leadership, and attention to detail.

  • Proven track record of scientific accomplishments demonstrated by publications in high-impact journals.

  • Ability to work in a collaborative, fast-paced environment .

  • Team-based candidate interested in a fast-paced, exciting, start-up environment!

Interested candidates should send their resume to careers@tcr2.com