Project Manager, Program Management

TCR² Therapeutics Inc. is an immuno-oncology company developing novel cancer therapies that unleash the full signaling power of complete T cell receptors (TCR). TCR² has developed a unique proprietary TRuC™ platform which can reprogram the natural TCR complex to recognize specific antigens found on tumors where they elicit rapid killing of cancer cells. The company has demonstrated activity against both hematological and solid tumor targets in preclinical models and believes its TRuC™-reprogrammed T cells will serve as the engine for important therapies.  TCR² was founded by MPM Capital and has scientific operations in Cambridge, MA to leverage best-in-class technologies and nucleate top-tier academic laboratories around the world.

TCR² Therapeutics is seeking a strong and skilled project manager to help build out the Program Management and Clinical Development Group.  This person will support the Program Leader to successfully execute projects, clinical development strategies and portfolio scenario-building and planning. The Project Manager is a key member of the team and will partner with internal team leaders and external partners to develop, track, and implement various clinical development projects to support TCR² Therapeutics’ development programs. The ideal candidate will identify, implement, and organize programs across cross-functional teams. The Project Manager will collaborate with teams to support development of program strategy, operational dependencies and timelines through completion across therapeutic programs.


  • Manage fast-paced, complex therapeutic development projects focused on cellular therapy in oncology (solid tumor and hematology) from the early stages of development to clinical proof-of-concept 

  • Track and monitor key milestones and decision points to drive delivery of project objectives

  • Assist the Program Leader in assuring a high-performance team spirit and high functioning team 

  • Provide a proactive approach to driving projects and identifying areas for risk mitigation

  • Coordinate and facilitate cross-functional and cross-organizational project meetings to drive actions and decision making

  • Must have strong interpersonal skills capable of working with a diverse group of people

  • Identify and help manage risks, conflicts and barriers to project success

  • Directly manage projects with minimal supervision

  • Identify deliverables and inter-dependencies associated with projects 

  • Maintain and update high-level and detailed timelines with input from the functional departments, ensuring that the functional timelines are aligned with development project and study team timelines

  • Incorporate financial and resource allocation aspects into project plans

  • Track the various parts of the timeline with the sub-teams and escalate issues, participating in resolution 

  • Establish a close partnering relationship with the clinical study teams and study managers to follow up on execution of clinical programs 

  • Coordinate compilation of Integrated Development Plans, and other tools and documents development of Project Management tools, templates, processes in collaboration with cross-functional teams

  • Create, maintain and optimize program dashboards 

  • Support preparation of periodic progress reports/program status metrics, meeting minutes and ad hoc reports as required

  • Ensure project team activities and decisions are clearly communicated, documented and archived, act as a primary contact for project team related information 

  • Partner with Project Teams to implement best practices across project teams e.g., resource capacity planning, project risk management, team performance, timeline development, portfolio management 

  • Assure that the TCR² Therapeutics’ values are demonstrated in all aspects of the team work 


  • Bachelors Degree in life sciences or a health-related field with a minimum of at least 5 years’ experience Biotech/Pharma and 3 years in Project Management or equivalent required.

  • Advanced degree (MS or MBA) and PMP certification desired but not required

Skills and Abilities:

  • Prior experience in development of biologics is preferred and experience with gene or cell therapy discovery and development is a plus 

  • Broad knowledge of the clinical development and biopharmaceutical manufacturing process

  • Strong analytical, problem-solving, and critical thinking skills

  • Must be able to interact and communicate effectively at all levels of the organization 

  • Must be competent in utilizing information technology systems and project management tools including systems (MS project, One Pager, Microsoft Visio, Excel and others) 

  • Excellent organizational and time management skills

  • The ability to independently lead several projects simultaneously, an adaptive working style, and a creative and thoughtful approach to problem solving

  • Thrives in a fast-paced and evolving environment

Skills and Abilities:

  • Travel is not frequently required (<5%) 

Interested candidates should send their resume to