Research Associate/ Senior Research Associate, Immuno-Pharmacology
TCR² Therapeutics Inc. is an immuno-oncology company developing novel cancer therapies that unleash the full signaling power of complete T cell receptors (TCR). TCR² has developed a unique proprietary TRuC™ platform which can reprogram the natural TCR complex to recognize specific antigens found on tumors where they elicit rapid killing of cancer cells. The company has demonstrated activity against both hematological and solid tumor targets in preclinical models and believes its TRuC™-reprogrammed T cells will serve as the engine for important therapies. TCR² was founded by MPM Capital and has scientific operations in Cambridge, MA to leverage best-in-class technologies and nucleate top-tier academic laboratories around the world.
The successful candidate will join the immuno-pharmacology group to assist with evaluation of T cell therapeutics for oncology. The candidate will assist with mouse models of cancer including xenograft and syngeneic models. This position offers an exciting opportunity to be responsible for key aspects of the development of new TRuC-T cell therapies.
Establishment of subcutaneous and systemic tumor models, injection of tumor cells by subcutaneous and iv routes, and delivery of test article by iv injection
Monitoring of mouse body weight/health and tumor monitoring by caliper measurement and imaging
Propagation of tumor cell lines, maintenance of freezer tumor cell line stocks
Blood collection and processing, necropsy, and harvesting of tissues
Excellent record keeping, maintenance of lab notebook
BS/BA degree in Biological Sciences
In vivo mouse model expertise, including mouse tumor models
Excellent sterile technique and maintenance of cell lines
Familiarity with analysis of tissues/cells by flow cytometry desirable
Excellent communication/organizational skills and attention to detail is essential
Candidate must be well-organized, a team player and able to work collaboratively with Research groups
Interested candidates should send their resume to firstname.lastname@example.org