Research Associate/Senior Research Associate, Analytical Process Development

TCR² Therapeutics Inc. is an immuno-oncology company developing novel cancer therapies that unleash the full signaling power of complete T cell receptors (TCR). TCR² has developed a unique proprietary TRuC™ platform which can reprogram the natural TCR complex to recognize specific antigens found on tumors where they elicit rapid killing of cancer cells. The company has demonstrated activity against both hematological and solid tumor targets in preclinical models and believes its TRuC™-reprogrammed T cells will serve as the engine for important therapies.  TCR² was founded by MPM Capital and has scientific operations in Cambridge, MA to leverage best-in-class technologies and nucleate top-tier academic laboratories around the world.

The successful candidate will join the vector production group as part of the Process Development department for TCR²’s proprietary TRuC™ platform. This position will require execution of cell culture experiments, assisting the team in analysis of in-process samples, and support of the technology transfer to CMOs. The position represents an excellent opportunity for career development, working closely with experienced scientists, in a fast-paced and highly collaborative environment.

Responsibilities:

  • Learn and execute on all assays used by the analytical team (qPCR, ELISA, T-cell based assays).

  • Assist in the analysis and characterization of lentiviral vectors for use by multiple internal research groups.

  • Work with process development teams to investigate, improve, and implement advanced vector production processes.

  • Analyze results, solve problems, and troubleshoot assays.

  • Participate in assay development of established analytical tools and help develop new assays.

  • Develop and maintain various cell lines used in cell-based analytical assays.

  • Present data at internal and external meetings.

  • Support QA/QC activities in the process development group and for tech transfer of GMP ready processes.

  • Author protocols and SOPs, maintain laboratory notebook records in adherence with documentation standards.

Requirements:

  • B.S. degree in biochemistry, cell biology, immunology or related discipline with at least 1-2 years of experience, preferably in a cell and gene therapy biotech or pharmaceutical setting.Experience characterizing with viral vectors (production and characterization) is desirable.

  • Experience in analytical assay execution and development, particularly qPCR is required.

  • Excellent attention to detail and problem-solving skills, ability to analyze and interpret data.

  • Strong interpersonal and communication skills and enthusiasm to work both independently and collaboratively in an exciting startup environment!

Interested candidates should send their resume to careers@tcr2.com