Scientist, Manufacturing – Stevenage UK

TCR² Therapeutics Inc. is a clinical-stage immuno-oncology company developing the next generation of novel T cell therapies for patients suffering from cancer. Our proprietary TRuC™ (TCR Fusion Construct) T cells harness the natural T-cell receptor complex to recognize and kill cancer cells using the full power of T cell signaling pathways independent of HLA. TRuC-T cells have demonstrated superior anti-tumor activity in vivo compared to CAR-T cells while releasing lower levels of cytokines in preclinical studies.  TCR² was founded by MPM Capital and is headquartered in Cambridge, MA to leverage best-in-class technologies and nucleate top-tier academic laboratories from around the world.

TCR² has embarked on establishing a cGMP manufacturing operation in Hertfordshire (Stevenage), UK to provide manufacturing capacity for Phase 1 and 2 clinical trials for TRuC™ T cell product candidates.  The role that TCR² envisions is a Scientist with strong and demonstrable leadership skills that will be utilized in a manufacturing program at Catapult Cell and Gene Therapy Center.   

The successful candidate will join the Manufacturing Group to lead a team to manufacture genetically engineered T cell products.  This position offers an exciting opportunity be responsible for a key aspect of TCR² overall corporate strategy. 


  • Manage and maintain a GMP manufacturing facility to meet FDA, EU and MHRA guidelines.

  • Supervise and work with the core manufacturing teams in a cleanroom environment.

  • Serve as the technical resource for the manufacturing process.

  • Ensure conformity to the Quality Management System.

  • Prepare, review and revise SOPs and manufacturing reports.

  • Liaise with the Facility Management for coordination of manufacturing activities and warehousing of raw materials.

  • Review manufacturing records.


  • Ph. D. in biological sciences or related field and minimum of 3 years progressive experience in a cell therapy or related field in GMP manufacturing.

  • Experience with T cell therapy manufacturing preferred or an strong immunology background.

  • Familiarity with GMPs in conformance with EU, FDA and MHRA standards.

  • Outstanding interpersonal communication and organizational skills.

Interested candidates should send their resume to