Scientist/Senior Scientist, Vector Process Development

TCR² Therapeutics Inc. is an immuno-oncology company developing novel cancer therapies that unleash the full signaling power of complete T cell receptors (TCR). TCR² has developed a unique proprietary TRuC™ platform which can reprogram the natural TCR complex to recognize specific antigens found on tumors where they elicit rapid killing of cancer cells. The company has demonstrated activity against both hematological and solid tumor targets in preclinical models and believes its TRuC™-reprogrammed T cells will serve as the engine for important therapies.  TCR² was founded by MPM Capital and has scientific operations in Cambridge, MA to leverage best-in-class technologies and nucleate top-tier academic laboratories around the world.

The successful candidate will join the Process Development group in the production and optimization of lentiviral vectors, execution of upstream and downstream process experiments, and participation in the evaluation of new technologies in the development of a robust and scalable manufacturing process. The position represents an excellent opportunity for career development, working closely with experienced scientists in a fast-paced and highly collaborative environment.

Primary Responsibilities:

  • Optimize lentiviral transfection processes through design of experiment studies.

  • Perform and develop lentiviral manufacturing processes from small to large scale.

  • Develop, optimize, and execute suspension bioreactor processes to produce lentiviral vectors.

  • Write protocols and operating procedures for technology transfer.

  • Work effectively with CMOs for technology transfer and support.

  • Apply new protocols and establish new methodologies and techniques.

  • Analyze and document scientific results for IND enabling studies.

  • Lead research associates and scientists in interdepartmental programs.

  • Represent TCR² at scientific presentations and meetings.

  • Organize and prioritize work to meet timelines and ability to execute on multiple projects.

Requirements:

  • Ph.D. in cellular biology, virology, or related discipline with at least 4 years of experience, preferably in industry.

  • Prior experience with suspension cell bioreactor operations required.

  • Experience with lentiviral production in suspension reactors preferred.

  • Outstanding critical thinking and organizational skills, leadership, and attention to detail.

  • Proven track record of scientific accomplishments demonstrated by publications in high-impact journals.

  • Team-based candidate interested in a fast-paced, exciting, start-up environment!

Interested candidates should send their resume to careers@tcr2.com