Senior Research Associate, Downstream Process Development

TCR² Therapeutics Inc. is an immuno-oncology company developing novel cancer therapies that unleash the full signaling power of complete T cell receptors (TCR). TCR² has developed a unique proprietary TRuC™ platform which can reprogram the natural TCR complex to recognize specific antigens found on tumors where they elicit rapid killing of cancer cells. The company has demonstrated activity against both hematological and solid tumor targets in preclinical models and believes its TRuC™-reprogrammed T cells will serve as the engine for important therapies.  TCR² was founded by MPM Capital and has scientific operations in Cambridge, MA to leverage best-in-class technologies and nucleate top-tier academic laboratories around the world.

The successful candidate will join the vector production group as part of the Process Development department for TCR²’s proprietary TRuC™ platform. This position will require execution of cell culture experiments, assisting the team in analysis of in-process samples, and support of the technology transfer to CMOs. The position represents an excellent opportunity for career development, working closely with experienced scientists, in a fast-paced and highly collaborative environment.

Responsibilities:

  • Assist in the production of lentiviral vectors for use by multiple internal research groups.

  • Work with process development teams to investigate, improve, and implement advanced vector production processes.

  • Collaborate with the analytics team to complete analysis of intermediate samples to facilitate process improvement.

  • Analyze results, solve problems, and troubleshoot assays.

  • Develop and maintain various cell lines used in cell-based analytical assays.

  • Present data at internal and external meetings.

  • Author protocols and SOPs, maintain laboratory notebook records in adherence with documentation standards.

Requirements:

  • B.S./M.S. degree in biochemistry, cell biology, immunology or related discipline with at least 2-3 years of experience, preferably in a cell therapy biotech or pharmaceutical setting.

  • Experience working with viral vectors (production and characterization) is desirable.

  • Experience in analytical assay execution and development, particularly flow cytometry is a plus.

  • Experience with downstream purification (microfiltration and tangential flow filtration) is also a plus.

  • Excellent attention to detail and problem-solving skills, ability to analyze and interpret data.

  • Strong interpersonal and communication skills and enthusiasm to work both independently and collaboratively in an exciting startup environment!

Interested candidates should send their resume to careers@tcr2.com