Senior Research Associate, T Cell Process Development

TCR² Therapeutics Inc. is an immuno-oncology company developing novel cancer therapies that unleash the full signaling power of complete T cell receptors (TCR). TCR² has developed a unique proprietary TRuC™ platform which can reprogram the natural TCR complex to recognize specific antigens found on tumors where they elicit rapid killing of cancer cells. The company has demonstrated activity against both hematological and solid tumor targets in preclinical models and believes its TRuC™-reprogrammed T cells will serve as the engine for important therapies.  TCR² was founded by MPM Capital and has scientific operations in Cambridge, MA to leverage best-in-class technologies and nucleate top-tier academic laboratories around the world.

The successful candidate will join the Process Development group to work on optimization of our T cell manufacturing platform with a focus on cell culture and cell processing strategies, participation in the evaluation of new technologies, product characterization, and support of the technology transfer to CMOs. The position represents an excellent opportunity for career development, working closely with experienced scientists in a fast-paced and highly collaborative environment.

Responsibilities:

  • Explore and define any process parameters that are critical to the production of TRuC™ T-cells.

  • Collaborate with the viral vector group in improving transduction of primary T-cells.

  • Contribute to the development and production of TRuC™ T-cells for various pipeline programs and in-vivo animal studies.

  • Execute analytical assays to better characterize TRuC™ T-cells and their ability to target cancer cells.

  • Perform design of experiment studies involving innovative and novel approaches to maximize production and reduce COGs.

  • Analyze results, solve problems and troubleshoot assays.

  • Author protocols and SOPs, maintain laboratory notebook records in adherence with documentation standards.

Requirements:

  • B.S./M.S. degree in biochemistry, cell biology, immunology or related discipline with at least 2-3 years of experience, preferably in a cell therapy biotech or pharmaceutical setting.

  • Experience in analytical assay execution and development, particularly flow cytometry, ELISA, and cell based toxicity assays.

  • Experience working with lentiviral vectors and primary human T cells is highly desirable.

  • Excellent attention to detail and problem-solving skills, ability to analyze and interpret data.

  • Strong interpersonal and communication skills and enthusiasm to work both independently and collaboratively in an exciting startup environment!

    Interested candidates should send their resume to careers@tcr2.com