Senior Scientist, T Cell Engineering
TCR² Therapeutics Inc. is an immuno-oncology company developing novel cancer therapies that unleash the full signaling power of complete T cell receptors (TCR). TCR² has developed a unique proprietary TRuC™ platform which can reprogram the natural TCR complex to recognize specific antigens found on tumors where they elicit rapid killing of cancer cells. The company has demonstrated activity against both hematological and solid tumor targets in preclinical models and believes its TRuC™-reprogrammed T cells will serve as the engine for important therapies. TCR² was founded by MPM Capital and has scientific operations in Cambridge, MA to leverage best-in-class technologies and nucleate top-tier academic laboratories around the world.
TCR² has embarked on the development of allogeneic TRuC-T cells for the treatment of cancer. TCR² seeks a T-cell Immunologist at the Senior Scientist level to join T Cell Engineering group, developing and evaluating allogeneic TRuC-T cell programs.
The successful candidate will apply his/her strong immunology knowledge to innovate in the T cell therapy field while bringing strong leadership to the T Cell Engineering group. This position offers an exciting opportunity to be responsible for a key aspect of TCR² overall corporate strategy by offering life-saving therapies to cancer patients across a broad range of indications.
Generate and characterize engineered immune cells
Design and execute in vitro studies to characterize the function and phenotype of immune cells
Prepare and expand T-cells for in vivo experiments
Analyze, interpret and present research at internal and external meetings
Supervise and train team members
Contribute to the development of the allogeneic TRuC-T cell strategy
At least 4 years of post-doctoral experience
Team player able to promote teamwork and collaboration
Demonstrated knowledge in T-cell receptor biology
Experience with human primary T-cell isolation
Familiar with Luminex, MLR and cytotoxicity assays
Familiar with GvHD mouse models
Able to work independently with multicolor FACS panels
Previous work with genome editing cells preferred
Interested candidates should send their resume to firstname.lastname@example.org