Senior Scientist, T Cell Engineering

TCR² Therapeutics Inc. is an immuno-oncology company developing novel cancer therapies that unleash the full signaling power of complete T cell receptors (TCR). TCR² has developed a unique proprietary TRuC™ platform which can reprogram the natural TCR complex to recognize specific antigens found on tumors where they elicit rapid killing of cancer cells. The company has demonstrated activity against both hematological and solid tumor targets in preclinical models and believes its TRuC™-reprogrammed T cells will serve as the engine for important therapies.  TCR² was founded by MPM Capital and has scientific operations in Cambridge, MA to leverage best-in-class technologies and nucleate top-tier academic laboratories around the world.

TCR² has embarked on the development of allogeneic TRuC-T cells for the treatment of cancer. TCR² seeks a T-cell Immunologist at the Senior Scientist level to join T Cell Engineering group, developing and evaluating allogeneic TRuC-T cell programs.

The successful candidate will apply his/her strong immunology knowledge to innovate in the T cell therapy field while bringing strong leadership to the T Cell Engineering group. This position offers an exciting opportunity to be responsible for a key aspect of TCR² overall corporate strategy by offering life-saving therapies to cancer patients across a broad range of indications. 

Responsibilities:

  • Generate and characterize engineered immune cells

  • Design and execute in vitro studies to characterize the function and phenotype of immune cells

  • Prepare and expand T-cells for in vivo experiments

  • Analyze, interpret and present research at internal and external meetings

  • Supervise and train team members

  • Contribute to the development of the allogeneic TRuC-T cell strategy

Requirements:

  • At least 4 years of post-doctoral experience

  • Team player able to promote teamwork and collaboration

  • Demonstrated knowledge in T-cell receptor biology

  • Experience with human primary T-cell isolation

  • Familiar with Luminex, MLR and cytotoxicity assays

  • Familiar with GvHD mouse models

  • Able to work independently with multicolor FACS panels

  • Previous work with genome editing cells preferred

    Interested candidates should send their resume to careers@tcr2.com