Vice President, Platform Innovation

TCR² Therapeutics Inc. is an immuno-oncology company developing novel cancer therapies that unleash the full signaling power of complete T cell receptors (TCR). TCR² has developed a unique proprietary TRuC™ platform which can reprogram the natural TCR complex to recognize specific antigens found on tumors where they elicit rapid killing of cancer cells. The company has demonstrated activity against both hematological and solid tumor targets in preclinical models and believes its TRuC™-reprogrammed T cells will serve as the engine for important therapies.  TCR² was founded by MPM Capital and has scientific operations in Cambridge, MA to leverage best-in-class technologies and nucleate top-tier academic laboratories around the world.

The VP of Platform Innovation will lead and manage the internal T cell engineering, platform enhancement and antibody discovery groups to evolve the TRuC-T cells platform with TCR². This is an outstanding opportunity for a talented senior-level scientist to contribute to bringing a new class of T cell therapies to patients and gain valuable career experience in a growing company.  The qualified candidate will report directly to the Chief Scientific Officer.

Responsibilities:

  • Provide scientific leadership to innovate and evolve the TRuC-T cell platform

  • Provide direction to incorporate novel mechanisms into engineered T cells to overcome the hostile tumor microenvironment

  • Lead gene-editing efforts for the development of off-the-shelf TRuC-T cells

  • Provide strategic input into the research direction of our T cell programs

  • Establish and maintain a network of external academic collaborators

  • Oversee collaborative research programs with external partners

  • Work collaboratively with the Research and Process Development teams

  • Establish and maintain key relationships with global leaders in immuno-oncology and T cell therapy

  • Responsibility to manage timelines and maintain the department budget

  • Attend and present corporate/scientific information at relevant conferences

  • Hire, build and lead scientific teams of PhD level scientists and MS/BS level research associates build and manage groups of scientists and research associates

Requirements:

  • Ph.D. or M.D./Ph.D. in Immunology, Cell Biology, Molecular Biology or related discipline

  • Minimum of 12 years of experience in immunology research, industry experience highly preferred

  • 10+ years of scientific leadership and mentoring in immune-oncology or adoptive cell therapy

  • Expertise in interpreting data from immune cell functional assays to study and pre-clinical models of T cell therapies

  • Proven ability to champion, integrate and advance innovative concepts within a cross-functional team

  • Proven knowledge in T cell biology, molecular immunology, and gene editing technologies demonstrated by publications in top-tier scientific journals

  • Ability to lead teams by example and promote company culture

  • Motivated to build a culture of innovation with aspirations to develop the next generation of life-changing therapies

  • Experience in strategic planning, project leadership, laboratory and budget management

  • Effective communicator and leader with excellent organization skills

  • Experience in hiring, supervising, developing and evaluating employees

Interested candidates should send their resume to careers@tcr2.com